In the last two decades, the search for completely novel antibacterial agents has acquired a
new sense of urgency due to the remarkable rise of antibiotic resistance among key …

Sequencing of bacterial genomes has been progressing with breathtaking speed. Currently,
the genomes of 23 bacterial species are sequenced, with approximately 40 more …

In this era of genomic science, knowledge about biological function is integrated
increasingly with DNA sequence data. One area that has been significantly impacted by this …

The shrinking antibiotic development pipeline together with the global increase in antibiotic
resistant infections requires that new molecules with antimicrobial activity are developed …

Whole chromosome sequence of prokaryotes has provided the availability of multiple
bacterial pathogen sequence data and it has become a widely used tool in the drug …

▪ Abstract There is an urgent need to develop novel classes of antibiotics to counter the
threat of the spread of multiply resistant bacterial pathogens. The availability of the complete …

Over the past decade, the availability of complete microbial genome sequences has led to
changes in the strategies that are used to search for novel anti-infectives. However, despite …

Complete DNA sequence information has now been obtained for several prokaryotic
genomes, defining the entire genetic complement of these organisms. The collection of …

This chapter describes two key strategies for the discovery of new antibacterial agents and
illustrates the critical role played by genomics in each. The first approach is genomic target …

The emergence of antibiotic resistance and multi-drug resistance in bacterial pathogens
underscores the need for the development of novel classes of antibiotics. The availability of …