Periconceptional folate supplementation reduces the recurrence and occurrence risk of
neural tube defects (NTD) by as much as 70%, yet the protective mechanism remains …

Periconceptional folic acid supplementation prevents approximately 70% of neural tube
defects (NTDs). While most women carrying affected fetuses do not have deficient blood …

Neural tube defects (NTDs) are the most common congenital malformations and are
considered to have a multifactorial origin, having both genetic and environmental …

Neural tube defects (NTDs) are among the commonest human birth defects, affecting around
1 per 1,000 births [Copp et al., 2003]. A genetic basis for NTDs is implicated based on the …

Abstract Thermolabile 5, 10‐methylenetetrahydrofolate reductase (MTHFR) is the first folate‐
related variant to be associated with an increased risk of neural tube defects (NTDs). The …

Neural-tube defects (NTD) are common congenital malformations that can lead to severe
disability or even death. Periconceptional supplementation with the B-vitamin folic acid has …

Defects of neural tube closure are among the most common of all human malformations.
Epidemiological and genetic studies indicate that most of these defects are multifactorial in …

In this paper, we trace the history of current research into the genetic and biochemical
mechanisms that underlie folate‐preventable neural tube defects (NTDs). The inspired …

Folate administration substantially reduces the risk on neural tube defects (NTD). The
interest for a disturbed homocysteine (Hcy) metabolism in relation to NTD was raised by the …

Women who take folic acid periconceptionally reduce their risk of having a child with a
neural tube defect (NTD) by> 50%. A variant form of methylenetetrahydrofolate reductase …