The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of …

H Tlaskalová-Hogenová, R Štěpánková… - Cellular & molecular …, 2011 - nature.com
Metagenomic approaches are currently being used to decipher the genome of the
microbiota (microbiome), and, in parallel, functional studies are being performed to analyze …

[HTML][HTML] Dissecting the interplay between intestinal microbiota and host immunity in health and disease: lessons learned from germfree and gnotobiotic animal models

U Fiebiger, S Bereswill… - European Journal of …, 2016 - akjournals.com
This review elaborates the development of germfree and gnotobiotic animal models and
their application in the scientific field to unravel mechanisms underlying host—microbe …

[HTML][HTML] Impact of the gut microbiota on rodent models of human disease

AK Hansen, CHF Hansen, L Krych… - World journal of …, 2014 - ncbi.nlm.nih.gov
Traditionally bacteria have been considered as either pathogens, commensals or symbionts.
The mammal gut harbors 10 14 organisms dispersed on approximately 1000 different …

The microbiota and immune‐mediated diseases: Opportunities for therapeutic intervention

G Fitzgibbon, KHG Mills - European journal of immunology, 2020 - Wiley Online Library
A multitude of diverse microorganisms, termed the microbiota, reside in the gut, respiratory
tract, skin, and genital tract of humans and other animals. Recent advances in metagenomic …

[HTML][HTML] Recent advances on microbiota involvement in the pathogenesis of autoimmunity

E Gianchecchi, A Fierabracci - International journal of molecular sciences, 2019 - mdpi.com
Autoimmune disorders derive from genetic, stochastic, and environmental factors that all
together interact in genetically predisposed individuals. The impact of an imbalanced gut …

The effects of commensal microbiota on immune cell subsets and inflammatory responses

T Chinen, AY Rudensky - Immunological reviews, 2012 - Wiley Online Library
Billions of years of coevolution shaped the mutually beneficial relationships between
metazoans and symbiotic commensal microorganisms. Commensal microorganisms …

Comparative evaluation of establishing a human gut microbial community within rodent models

ML Wos-Oxley, A Bleich, APA Oxley, S Kahl… - Gut …, 2012 - Taylor & Francis
The structure of the human gut microbial community is determined by host genetics and
environmental factors, where alterations in its structure have been associated with the onset …

Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology

PG Falk, LV Hooper, T Midtvedt… - … and molecular biology …, 1998 - Am Soc Microbiol
Studying the cross talk between nonpathogenic organisms and their mammalian hosts
represents an experimental challenge because these interactions are typically subtle and …

[HTML][HTML] Gut microbiota in health and disease

I Sekirov, SL Russell, LCM Antunes… - Physiological …, 2010 - journals.physiology.org
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the
mammalian gastrointestinal tract. The composition of this microbial community is host …

[HTML][HTML] Rapidly expanding knowledge on the role of the gut microbiome in health and disease

MC Cénit, V Matzaraki, EF Tigchelaar… - Biochimica et Biophysica …, 2014 - Elsevier
The human gut is colonized by a wide diversity of micro-organisms, which are now known to
play a key role in the human host by regulating metabolic functions and immune …