Gastrointestinal tumor is an important factor threatening human health. Natural product-
based drug discovery is a popular paradigm for expanding the chemical space and …

A critical question in natural product-based drug discovery is how to translate the product
into drug-like molecules with optimal pharmacological properties. The generation of natural …

Gastric cancer represents a significant health burden worldwide. Previously, inspired by the
traditional Chinese medicine Wu-Chu-Yu to treat the spleen and stomach system for …

Evodiamine is a quinazolinocarboline alkaloid isolated from the fruits of traditional Chinese
herb Evodiae fructus. Previously, we identified N13-substituted evodiamine derivatives as …

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone
scaffold was designed by scaffold hopping. Structure–activity relationship studies led to the …

Evodiamine (Evo) is a quinazolinocarboline alkaloid found in Evodia rutaecarpa and
exhibits moderate antiproliferative activity. Herein, we report using a scaffold-hopping …

Topoisomerase has been found extremely high level of expression in hepatocellular
carcinoma (HCC) and proven to promote the proliferation and survival of HCC. Cancer …

Introduction: Human topoisomerase 1 (TOP1) is an important target of various anticancer
compounds. The design and discovery of inhibitors targeting TOP1 are of great significance …

To explore novel topoisomerase inhibitors with high activity and druggability, 3-aryl
isoquinoline alkaloids based on the corydamine modification and preliminary SARs of …

Natural products are important sources for the development of therapeutic medicine, among
which evodia fruit has a wide range of medicinal properties in traditional Chinese medicine …