The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2, 1, 3-
benzothiadiazole], a centrally acting muscle relaxant, was evaluated after subcutaneous or …

The antinociceptive, tolerance-developing and anti-withdrawal activities of tizanidine [5-
chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzo-thiadiazole] were investigated by …

Abstract Tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3-benzothiadiazole] is able to
increase the pain threshold in the tail-flick test in mice. The effect of tizanidine was …

The effect of drugs that influence the opioidergic and monoaminergic neuronal systems on
the antinociceptive action of tizanidine [5-chloro-4-(2-imidazolin-2-yl-amino)-2, 1, 3 …

The site of action of tizanidine (5-chloro-4-(2-imidazolin-2-yl-amino) 2, 1, 3-
benzothiadiazole) was investigated in a tail-flick test in comparison with clonidine and …

Experiments were performed in rats to determine if the [alpha] 2-adrenergic agonist
tizanidine has an antinociceptive effect when injected intrathecally, and whether the …

Tizanidine, an imidazoline derivative with alpha 2-receptor-mediated central muscle
relaxant activity, is in widespread clinical use for the treatment of spasticity. To evaluate its …

The antinociceptive activity of a 3 (2H)-pyridazinone derivative (18a) was investigated in
mice. 18a administered at doses which did not change either motor coordination or …

The effects of the centrally acting muscle relaxant tizanidine (DS 103-282) have been
examined on the responses of laminae IV and V dorsal horn neurones to peripheral noxious …

PURPOSE. Sympathetic nervous system stimulation, which releases noradrenalin,
influences the nociceptive activity that develops after tissue injury. The α2-adrenergic …