Many cystic fibrosis transmembrane conductance regulator (CFTR)-expressing epithelia
secrete bicarbonate (HCO3−)-containing fluids. Recent evidence suggests that defects in …

The secretory epithelia of the pancreatic duct and airway share the ability to generate HCO3-
-rich fluids. They both express CFTR (cystic fibrosis transmembrane conductance regulator) …

Pancreatic duct cells secrete bicarbonate-rich fluids, which are important for maintaining the
patency of pancreatic ductal trees as well as intestinal digestive function. The bulk of …

Defective HCO3–and fluid secretion are hallmarks of the pathophysiology of the pancreas of
cystic fibrosis patients. Recently, impaired HCO3–secretion has been shown in most tissues …

BACKGROUND & AIMS: Pancreatic bicarbonate (HCO3−) secretion is important for a
healthy pancreas as well as digestive physiology. However, how human pancreatic duct …

ABSTRACT HCO 3–-rich fluid in the pancreatic juice (2~ 3 L/day) is secreted by epithelial
cells lining the pancreatic duct tree, while digestive enzymes are secreted by acinar cells …

Bicarbonate serves many functions in our body. It is the predominant buffer maintaining a
physiological pH in the blood and within our cells. It is also essential for proper digestion of …

Patients with cystic fibrosis demonstrate a defect in HCO3-secretion by their pancreatic duct
cells. However, attempts toward understanding or correcting this defect have been …

This study addresses the mechanisms by which a defect in CFTR impairs pancreatic duct
bicarbonate secretion in cystic fibrosis. We used control (PANC‐1) and CFTR‐deficient …

Pancreatic duct epithelium secretes a HCO3−-rich fluid by a mechanism dependent on
cystic fibrosis transmembrane conductance regulator (CFTR) in the apical membrane …