[HTML][HTML] Effects of weight loss and exercise on insulin resistance, and intramyocellular triacylglycerol, diacylglycerol and ceramide
JJ Dubé, F Amati, FGS Toledo, M Stefanovic-Racic… - Diabetologia, 2011 - Springer
Aims/hypothesis Intramyocellular lipids, including diacylglycerol (DAG) and ceramides, have
been linked to insulin resistance. This randomised repeated-measures study examined the …
been linked to insulin resistance. This randomised repeated-measures study examined the …
Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
F Amati, JJ Dubé, E Alvarez-Carnero, MM Edreira… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Chronic exercise and obesity both increase intramyocellular triglycerides
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
(IMTGs) despite having opposing effects on insulin sensitivity. We hypothesized that …
[HTML][HTML] Obesity-associated insulin resistance in skeletal muscle: role of lipid accumulation and physical inactivity
K Eckardt, A Taube, J Eckel - Reviews in Endocrine and Metabolic …, 2011 - Springer
An alarming increase in the prevalence of obesity, type 2 diabetes mellitus, and associated
diseases can be observed world-wide during the past 20 years. In obesity, profound …
diseases can be observed world-wide during the past 20 years. In obesity, profound …
Influence of gender, obesity, and muscle lipase activity on intramyocellular lipids in sedentary individuals
C Moro, JE Galgani, L Luu, M Pasarica… - The Journal of …, 2009 - academic.oup.com
Context: Obesity and type 2 diabetes are associated with elevated intramyocellular lipids
(IMCLs) and insulin resistance. Objective: We tested the hypothesis that skeletal muscle …
(IMCLs) and insulin resistance. Objective: We tested the hypothesis that skeletal muscle …
[HTML][HTML] Lipid-induced insulin resistance in skeletal muscle: the chase for the culprit goes from total intramuscular fat to lipid intermediates, and finally to species of …
SM Kitessa, MY Abeywardena - Nutrients, 2016 - mdpi.com
The skeletal muscle is the largest organ in the body. It plays a particularly pivotal role in
glucose homeostasis, as it can account for up to 40% of the body and for up to 80%–90% of …
glucose homeostasis, as it can account for up to 40% of the body and for up to 80%–90% of …
Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content
OBJECTIVE We tested the primary hypotheses that sphingolipid and diacylglycerol (DAG)
content is higher within insulin-resistant muscle and that the association between …
content is higher within insulin-resistant muscle and that the association between …
[HTML][HTML] Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans
BC Bergman, DM Hunerdosse, A Kerege, MC Playdon… - Diabetologia, 2012 - Springer
Aims/hypothesis We sought to evaluate if the cellular localisation and molecular species of
diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. Methods …
diacylglycerol (DAG) were related to insulin sensitivity in human skeletal muscle. Methods …
Muscular diacylglycerol metabolism and insulin resistance
S Timmers, P Schrauwen, J de Vogel - Physiology & behavior, 2008 - Elsevier
Failure of insulin to elicit an increase in glucose uptake and metabolism in target tissues
such as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes …
such as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes …
[HTML][HTML] Intracellular localization of diacylglycerols and sphingolipids influences insulin sensitivity and mitochondrial function in human skeletal muscle
L Perreault, SA Newsom, A Strauss, A Kerege… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Accumulation of diacylglycerol (DAG) and sphingolipids is thought to
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …
promote skeletal muscle insulin resistance by altering cellular signaling specific to their …
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
CR Bruce, AB Thrush, VA Mertz… - American journal …, 2006 - journals.physiology.org
Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance, reflected by
reduced rates of FA oxidation and accumulation of lipids. It has been suggested that …
reduced rates of FA oxidation and accumulation of lipids. It has been suggested that …