Objective The link between a reduced capacity for skeletal muscle mitochondrial fatty acid
oxidation (FAO) and lipotoxicity in human insulin resistance has been the subject of intense …

Obesity is associated with skeletal muscle insulin resistance, which is a crucial step in the
development of type 2 diabetes. Among the mechanisms by which obesity may lead to …

Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations
are associated with diminished insulin sensitivity in skeletal muscle. This lipid accumulation …

Aims/hypothesis We sought to determine putative relationships among improved
mitochondrial respiration, insulin sensitivity and altered skeletal muscle lipids and …

We previously reported an “athlete's paradox” in which endurance-trained athletes, who
possess a high oxidative capacity and enhanced insulin sensitivity, also have higher …

Aims/hypothesis In skeletal muscle, ceramides may be involved in the pathogenesis of
insulin resistance through an attenuation of insulin signalling. This study investigated total …

Obesity is a risk factor for metabolic diseases. Intramuscular lipid accumulation of
ceramides, diacylglycerols, and long chain acyl-CoA is responsible for the induction of …

Derangements in skeletal muscle fatty acid (FA) metabolism associated with insulin
resistance in obesity appear to involve decreased FA oxidation and increased accumulation …

Purpose and methods This review presents established knowledge on the effects of physical
activity (PA) on whole-body insulin sensitivity (SI) and summarises the findings of recent …

Dysfunctional adipose tissue is associated with an increased risk of developing type 2
diabetes (T2D). One characteristic of a dysfunctional adipose tissue is the reduced …