Intramuscular triglyceride (IMTG) concentration is elevated in insulin-resistant individuals
and was once thought to promote insulin resistance. However, endurance-trained athletes …

The inability of insulin to stimulate glucose metabolism in skeletal muscle is a classic
characteristic of type 2 diabetes, but this insulin resistance entails altered patterns of lipid …

Obesity predisposes individuals to the development of insulin resistance, which is a risk
factor for type 2 diabetes, and muscle plays a central role in this phenomenon. Insulin …

OBJECTIVE It has been proposed that skeletal muscle insulin resistance arises from the
accumulation of intramyocellular lipid metabolites that impede insulin signaling, including …

Objectives: To address the potential effects of weight loss and physical activity (WL+ Ex) on
intramyocellular lipid (IMCL) and lipid droplet size in overweight and obese previously …

SUMMARY 1 Insulin resistance occurs when normal amounts of insulin are inadequate to
produce a normal insulin response from cells. This is important in the context of whole‐body …

With the increasing prevalence of obesity, research has focused on the molecular
mechanism (s) linking obesity and skeletal muscle insulin resistance. Metabolic alterations …

Both Roux-en-Y gastric bypass (RYGB) surgery and exercise can improve insulin sensitivity
in individuals with severe obesity. However, the impact of RYGB with or without exercise on …

Increased dietary fat intake and lipolysis result in excessive lipid availability, which relates to
impaired insulin sensitivity. Over the last years, several mechanisms possibly underlying …

Skeletal muscle insulin resistance entails dysregulation of both glucose and fatty acid
metabolism. This study examined whether a combined intervention of physical activity and …