Molecular aspects of the tachykinin receptors Page 1 Regulatory Peptides, 43 (1993) 21-35
21 й 1993 Elsevier Science Publishers BV All rights reserved 0167-0115/93/$06.00 …

We report four human tachykinins, endokinins A, B, C, and D (EKA–D), encoded from a
single tachykinin precursor 4 gene that generates four mRNAs (α, β, γ, and δ). Tachykinin 4 …

Tachykinins exert a broad range of actions in the mammalian nervous system. While much is
known about the localization of peptides derived from one of the two mammalian tachykinin …

Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

Besides Substance P (SP)[I], two tachykinins have been isolated from the brain and the
spinal cord of mammals, ie Neurokinin A (NKA, also named Substance K and Neuromedin …

The use of selective agonists in both functional and binding studies has provided
unequivocal evidence for the existence of three types of tachykinin receptor (NK 1, NK 2 and …

The recent zsolatzon of substance K and neuromedm K, two new mammahan tachykimns,
suggests the possible existence of mulaple receptor sub-types for substance P and related …

Fig. 1. A serpentine model of the NK1 receptor and structures of human tachykinin peptides
and some relevant analogues. For the ligands, the residues corresponding to the substance …

Understanding the physiological role of tachykinins requires precise cellular and subcellular
localization of their receptors. We raised antisera by immunizing rabbits with peptides …

Tachykinins (TKs) constitute the largest vertebrate brain/gut peptide family. Since discovery
of Substance P as a structurally unidentified vasodilatory and contractile compound in 1931 …