The tumor suppressor PTEN was originally identified as a negative regulator of the
phosphoinositide 3-kinase (PI3K) signaling, a main regulator of cell growth, metabolism and …

The PI3K-Akt pathway is a major survival pathway activated in cancer. Efforts to develop
targeted therapies have not been fully successful, mainly because of extensive internal …

PTEN/PI3K/AKT constitutes an important pathway regulating the signaling of multiple
biological processes such as apoptosis, metabolism, cell proliferation and cell growth. PTEN …

PI3-kinase and PTEN are major positive and negative regulators, respectively, of the PI3-
kinase pathway, which regulates growth, survival, and proliferation. These key signaling …

Regulation of the PI-3 kinase (PI3K)/Akt signalling pathway is essential for maintaining the
integrity of fundamental cellular processes, cell growth, survival, death and metabolism, and …

The PI-3 kinase pathway is a major driving force for human cancer. One common way of
stimulating the PI-3 kinase pathway occurs through inactivation of the PTEN tumor …

Conclusion In conclusion, direct genetic alterations leading to deregulated PI3K/Akt
signalling are common in a significant fraction of human malignancies. The forthcoming …

The tumor suppressor phosphatase and tensin homolog (PTEN) is a nonredundant
phosphatase, counteracting one of the most critical cancer-promoting pathways: the …

When PI3K (phosphatidylinositol-3 kinase) is activated by receptor tyrosine kinases, it
phosphorylates PIP2 to generate PIP3 and activates the signaling pathway. Phosphatase …

Genetic alterations targeting the PTEN tumor suppressor gene are among the most
frequently noted somatic mutations in human cancers. Such lesions have been noted in …