As a consequence of recent discoveries of intimate involvement of mitochondria with key
cellular processes, there has been a resurgence of interest in all aspects of mitochondrial …

Numerous age‐related human diseases have been associated with deficiencies in cellular
energy production. Moreover, genetic alterations resulting in mitochondrial dysfunction are …

Eukaryotes control nearly every cellular process in part by modulating the transcription of
genes encoded by their nuclear genome. However, these cells are faced with the added …

Mitochondria are central hubs for cellular metabolism, coordinating a variety of metabolic
reactions crucial for human health. Mitochondria provide most of the cellular energy via their …

Mitochondria are specialized compartments that produce requisite ATP to fuel cellular
functions and serve as centers of metabolite processing, cellular signaling, and apoptosis …

Mammalian mitochondrial DNA (mtDNA) is a circular double-stranded DNA genome of~
16.5 kilobase pairs (kb) that encodes 13 catalytic proteins of the ATP-producing oxidative …

Human mitochondria contain multiple copies of a small double-stranded DNA genome that
encode 13 components of the electron-transport chain and RNA components that are …

Mitochondria are peculiar organelles whose proper function depends on the crosstalk
between two genomes, mitochondrial and nuclear. The human mitochondrial genome …

For more than a century after their discovery, mitochondria were viewed almost exclusively
as ATP-generating metabolic units. This view changed with the discovery of the …

We are witnessing a period of renewed interest in the biology of the mitochondrion. The
mitochondrion serves a critical function in the maintenance of cellular energy stores …