Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells
Isoorientin (ISO) is a flavonoid compound that can be extracted from several plant species,
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …
MAPK signaling pathways regulate mitochondrial-mediated apoptosis induced by isoorientin in human hepatoblastoma cancer cells
L Yuan, J Wang, H Xiao, W Wu, Y Wang… - Food and Chemical …, 2013 - Elsevier
Isoorientin (ISO)(CAS RN: 4261-42-1) is a flavonoid compound that can be extracted from
several plant species, such as Phyllostachys pubescens, Patrinia, and Drosophyllum …
several plant species, such as Phyllostachys pubescens, Patrinia, and Drosophyllum …
[HTML][HTML] Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS‑regulated MAPK, STAT3 and NF‑κB signaling pathways
WT Xu, GN Shen, TZ Li, Y Zhang… - International …, 2020 - spandidos-publications.com
Isoorientin (ISO) is a naturally occurring C‑glycosyl flavone that has various pharmacological
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …
properties, such as anti‑bacterial and anti‑inflammatory effects. However, its underlying …
Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 …
L Yuan, S Wei, J Wang, X Liu - Journal of Agricultural and Food …, 2014 - ACS Publications
Cell death is closely related to autophagy under some circumstances; however, the effect of
isoorientin (ISO) on autophagy and the interplay between apoptosis and autophagy in …
isoorientin (ISO) on autophagy and the interplay between apoptosis and autophagy in …
Isoorientin from Gypsophila elegans induces apoptosis in liver cancer cells via mitochondrial-mediated pathway
X Lin, J Wei, Y Chen, P He, J Lin, S Tan, J Nie… - Journal of …, 2016 - Elsevier
Ethnopharmacological relevance Gypsophila elegans has been used as a traditional herbal
medicine for treating immune disorders and chronic liver diseases in China. The aim of this …
medicine for treating immune disorders and chronic liver diseases in China. The aim of this …
Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways
S Li, H Liu, Z Lin, Z Li, Y Chen, B Chen, L Huang, X Lin… - Phytomedicine, 2022 - Elsevier
Background Chemotherapy drugs especially anthracyclines are widely used in the treatment
of hematological malignancies and solid tumors. However, their clinical application is limited …
of hematological malignancies and solid tumors. However, their clinical application is limited …
Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells
T Ye, J Su, C Huang, D Yu, S Dai, X Huang… - OncoTargets and …, 2016 - Taylor & Francis
Isoorientin (or homoorientin) is a flavone, which is a chemical flavonoid-like compound, and
a 6-C-glucoside of luteolin. Isoorientin has been demonstrated to have anti-cancer activities …
a 6-C-glucoside of luteolin. Isoorientin has been demonstrated to have anti-cancer activities …
[HTML][HTML] Isoorientin ameliorates APAP-induced hepatotoxicity via activation Nrf2 antioxidative pathway: The involvement of AMPK/Akt/GSK3β
X Fan, H Lv, L Wang, X Deng, X Ci - Frontiers in pharmacology, 2018 - frontiersin.org
Oxidative stress has been highlighted as therapeutic targets for acetaminophen (APAP)-
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
induced hepatotoxicity. Isoorientin (Iso), a well-known flavonoid-like compound, has been …
Effect of isoorientin on intracellular antioxidant defence mechanisms in hepatoma and liver cell lines
L Yuan, J Wang, W Wu, Q Liu, X Liu - Biomedicine & Pharmacotherapy, 2016 - Elsevier
Isoorientin (ISO) is considered one of the most important flavonoid-like compounds
responsible for health benefits, including the prevention of liver damage as well as …
responsible for health benefits, including the prevention of liver damage as well as …
Isoorientin reverses lung cancer drug resistance by promoting ferroptosis via the SIRT6/Nrf2/GPX4 signaling pathway
S Feng, Y Li, H Huang, H Huang, Y Duan… - European Journal of …, 2023 - Elsevier
Cisplatin, or DDP, is a highly successful and well-known chemotherapy drug used to treat
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …
cancer. Acquired resistance to chemotherapy is a major clinical concern, yet the …