Colorectal carcinoma is one of the utmost diagnosed cancer with a steep increase in
mortality rate. The incidence has been increasing in developing countries like India due to a …

Oridonin, a diterpenoid isolated from the plant Rabdosia rubescens, induces human
epidermoid carcinoma A431 cell death through apoptosis and tyrosine kinase pathway. To …

Programmed necrosis is established as a new form of programmed cell death and is
emerging as a new strategy of treatment for cancers. Pristimerin is a natural chemical with …

Isoorientin (Iso), a natural bioactive flavonoid, possesses significant anti-tumor and anti-
oxidant activities. Benzo [a] pyrene (BaP) is a food processing injurant with carcinogenicity …

Oridonin, a diterpenoid isolated from Rabdosia rubescences, could induce apoptosis
through the generation of reactive oxygen species (ROS) in human hepatoma HepG2 cells …

Isorhamnetin (ISO) is a flavonoid from plants of the Polygonaceae family and is also an
immediate metabolite of quercetin in mammals. To date, the anti‑tumor effects of ISO and the …

Liver cancer remains a leading cause of death, despite advances in anti-cancer therapies.
To develop novel drugs, natural products are being considered as a good source for …

The biological function of the natural ent-kaurene diterpenoid isolated from genus Isodon,
oridonin, has been intensively studied. However, its mechanism studies and clinical …

Isodon diterpenoids have received considerable phytochemical and biological attention for
their strong antitumor activity with low toxicity. In this study, ExcisaninA, a diterpenoid …

Oridonin was reported to induce L929 cell apoptosis via ROS-mediated mitochondrial and
ERK pathways; however, the precise mechanisms by which oridonin induces cell death …