The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy
A Singh, J Ham, JW Po, N Niles, T Roberts, CS Lee - Cells, 2021 - mdpi.com
Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
I Landa, T Ibrahimpasic, L Boucai… - The Journal of …, 2016 - Am Soc Clin Investig
BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …
Genomic landscape of poorly differentiated and anaplastic thyroid carcinoma
B Xu, R Ghossein - Endocrine pathology, 2016 - Springer
Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are
aggressive thyroid tumors associated with a high mortality rate of 38–57% and almost 100 …
aggressive thyroid tumors associated with a high mortality rate of 38–57% and almost 100 …
Pathogenesis of cancers derived from thyroid follicular cells
The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …
Genomic hallmarks of thyroid neoplasia
TJ Giordano - Annual Review of Pathology: Mechanisms of …, 2018 - annualreviews.org
The genomic landscape of thyroid cancers that are derived from follicular cells has been
substantially elucidated through the coordinated application of high-throughput genomic …
substantially elucidated through the coordinated application of high-throughput genomic …
Progress in treating advanced thyroid cancers in the era of targeted therapy
CC Lubitz, PM Sadow, GH Daniels, LJ Wirth - Thyroid, 2021 - liebertpub.com
Background: Thyroid cancer is a common malignancy whose detection has increased
significantly in past decades. Most of the increased incidence is due to detection of early …
significantly in past decades. Most of the increased incidence is due to detection of early …
Molecular markers guiding thyroid cancer management
C Nylén, R Mechera, I Maréchal-Ross, V Tsang… - Cancers, 2020 - mdpi.com
The incidence of thyroid cancer is rapidly increasing, mostly due to the overdiagnosis and
overtreatment of differentiated thyroid cancer (TC). The increasing use of potent preclinical …
overtreatment of differentiated thyroid cancer (TC). The increasing use of potent preclinical …
Perspective: lessons learned from molecular genetic studies of thyroid cancer—insights into pathogenesis and tumor-specific therapeutic targets
JA Fagin - Endocrinology, 2002 - academic.oup.com
Thyroid cancer derived from follicular cells is the most common endocrine malignancy. The
past decade has seen progress in our understanding of the pathogenesis of the various …
past decade has seen progress in our understanding of the pathogenesis of the various …
Molecular landscape of thyroid cancer continues to be deciphered
YE Nikiforov - Nature Reviews Endocrinology, 2016 - nature.com
Studies published in 2015 have continued to unravel the genomic landscape of thyroid
cancer, particularly of its less common forms (such as medullary and anaplastic carcinomas) …
cancer, particularly of its less common forms (such as medullary and anaplastic carcinomas) …
Heterogeneity of thyroid cancer
E Chmielik, D Rusinek, M Oczko-Wojciechowska… - Pathobiology, 2018 - karger.com
There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …