The genomic landscape of thyroid cancer tumourigenesis and implications for immunotherapy

A Singh, J Ham, JW Po, N Niles, T Roberts, CS Lee - Cells, 2021 - mdpi.com
Thyroid cancer is the most prevalent endocrine malignancy that comprises mostly indolent
differentiated cancers (DTCs) and less frequently aggressive poorly differentiated (PDTC) or …

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

I Landa, T Ibrahimpasic, L Boucai… - The Journal of …, 2016 - Am Soc Clin Investig
BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …

Genomic landscape of poorly differentiated and anaplastic thyroid carcinoma

B Xu, R Ghossein - Endocrine pathology, 2016 - Springer
Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are
aggressive thyroid tumors associated with a high mortality rate of 38–57% and almost 100 …

Pathogenesis of cancers derived from thyroid follicular cells

JA Fagin, GP Krishnamoorthy, I Landa - Nature reviews Cancer, 2023 - nature.com
The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

Genomic hallmarks of thyroid neoplasia

TJ Giordano - Annual Review of Pathology: Mechanisms of …, 2018 - annualreviews.org
The genomic landscape of thyroid cancers that are derived from follicular cells has been
substantially elucidated through the coordinated application of high-throughput genomic …

Progress in treating advanced thyroid cancers in the era of targeted therapy

CC Lubitz, PM Sadow, GH Daniels, LJ Wirth - Thyroid, 2021 - liebertpub.com
Background: Thyroid cancer is a common malignancy whose detection has increased
significantly in past decades. Most of the increased incidence is due to detection of early …

Molecular markers guiding thyroid cancer management

C Nylén, R Mechera, I Maréchal-Ross, V Tsang… - Cancers, 2020 - mdpi.com
The incidence of thyroid cancer is rapidly increasing, mostly due to the overdiagnosis and
overtreatment of differentiated thyroid cancer (TC). The increasing use of potent preclinical …

Perspective: lessons learned from molecular genetic studies of thyroid cancer—insights into pathogenesis and tumor-specific therapeutic targets

JA Fagin - Endocrinology, 2002 - academic.oup.com
Thyroid cancer derived from follicular cells is the most common endocrine malignancy. The
past decade has seen progress in our understanding of the pathogenesis of the various …

Molecular landscape of thyroid cancer continues to be deciphered

YE Nikiforov - Nature Reviews Endocrinology, 2016 - nature.com
Studies published in 2015 have continued to unravel the genomic landscape of thyroid
cancer, particularly of its less common forms (such as medullary and anaplastic carcinomas) …

Heterogeneity of thyroid cancer

E Chmielik, D Rusinek, M Oczko-Wojciechowska… - Pathobiology, 2018 - karger.com
There are 5 main histological types of thyroid cancers (TCs): papillary, follicular (also known
as differentiated), poorly differentiated, anaplastic (the most aggressive form), and medullary …