Transgenic animals that over-or underexpress a protein of interest have been used to study
obesity development, prevention, and susceptibility to diet-induced obesity such as a high …

Within the past 3 years, all of the extant single-gene mutations resulting in obesity in rodents
have been cloned. These mutations are Yellow, obese, diabetes, fat, and tubby. The rat fatty …

Our understanding of body weight regulation has been greatly advanced by the
characterization of previously existing mutations in mice that cause obesity. Subsequent …

The traditional view of adipose tissue as a passive energy reservoir has changed. Adipose
tissue is a complex, highly active metabolic and endocrine organ. With obesity as an …

Rodent models in which monogenic alterations cause obesity in the absence of
environmental changes have confirmed earlier inferences regarding the biologic/genetic …

Animals that deposit excessive amounts of body fat and become obese as result of
inheritance of single Mendelian genes for obesity have been known since 1905, when …

Many genetic manipulations have created models of obesity, leanness or resistance to
dietary obesity in mice, often providing insights into molecular mechanisms that affect …

Obesity is a complex phenotype which “resolves” the influences of genes, development and
environment. In any individual—and in the same individual at different times of life—the …

Obesity results from prolonged imbalance of energy intake and energy expenditure. Animal
models have provided a fundamental contribution to the historical development of …

Background Obesity stems from a prolonged imbalance between the levels of energy intake
and expenditure, with the resultant surplus being stored as body lipids. Our understanding of …