Summary Alveolar epithelial type 2 (AT2) cells integrate signals from multiple molecular
pathways to proliferate and differentiate to drive regeneration of the lung alveolus. Utilizing …

Lung is a complex organ lined with epithelial cells. In order to maintain its homeostasis and
normal functions following injuries caused by varied extraneous and intraneous insults, such …

While the adult murine lung utilizes multiple compartmentally restricted progenitor cells
during homeostasis and repair, much less is known about the progenitor cells from the …

The application of conditional reprogramming culture (CRC) methods to nasal airway
epithelial cells would allow more wide-spread incorporation of primary airway epithelial …

The extent of lung regeneration following catastrophic damage and the potential role of adult
stem cells in such a process remains obscure. Sublethal infection of mice with an H1N1 …

Lung stem cells are instructed to produce lineage-specific progeny through unknown factors
in their microenvironment. We used clonal 3D cocultures of endothelial cells and distal lung …

We used CDK4/hTERT–immortalized normal human bronchial epithelial cells (HBEC) from
several individuals to study lung cancer pathogenesis by introducing combinations of …

Recent studies have shown that mesothelial progenitors contribute to mesenchymal
lineages of developing organs. To what extent the overlying mesothelium contributes to lung …

Dysfunction of alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung
alveoli, is implicated in pulmonary disease pathogenesis, highlighting the importance of …

Alveolar type 1 (AT1) cells cover> 95% of the gas exchange surface and are extremely thin
to facilitate passive gas diffusion. The development of these highly specialized cells and its …