Oxidative stress plays an important role in diabetic vascular dysfunction. The sources and
regulation of reactive oxygen species production in diabetic vasculature continue to be …

We tested the hypothesis that short-term treatment of mice with Type 2 diabetes mellitus
(DM) with rosiglitazone (ROSI), an agonist of peroxisome proliferator-activated receptor-γ …

Endothelial dysfunction plays a key role in the pathogenesis of diabetic vascular disease.
Herein, we have analyzed if the peroxisome proliferator-activated receptor-β/-δ (PPARβ/δ) …

Recently, we demonstrated that the peroxisome proliferator-activated receptor-γ (PPAR-γ)
ligands, either 15-deoxy-Δ12, 14-prostaglandin J2 (15d-PGJ2) or ciglitazone, increased …

Background—Peroxisome proliferator–activated receptor (PPAR) signaling pathways have
been reported to exert anti-inflammatory effects and attenuate atherosclerosis formation …

We examined the effects of a variety of ligands/activators of the peroxisome proliferator-
activated receptor (PPAR) on the expression of the superoxide scavenger enzyme, Cu 2+ …

High glucose induces vascular smooth muscle cell (SMC) dysfunction by generating
oxidative stress attributable, in part, to the up-regulated NADPH oxidases (Nox). We have …

Activation of peroxisome proliferator activated receptor (PPAR) α and its protective role in
cardiovascular function has been reported but the exact mechanism (s) involved is not clear …

Recent evidence highlights the therapeutic potential of peroxisome proliferator–activated
receptor-δ (PPARδ) agonists to increase insulin sensitivity in diabetes. However, the role of …

Peroxisome proliferator-activated receptor (PPAR)-δ is a nuclear hormone receptor that is
mainly involved in lipid metabolism. Recent studies have suggested that PPAR-δ agonists …