Mammalian gene expression patterns are controlled by regulatory elements, which interact
within topologically associating domains (TADs). The relationship between activation of …

Genomic information is selectively used to direct spatial and temporal gene expression
during differentiation. Interactions between topologically associating domains (TADs) and …

Animal interphase chromosomes are organized into topologically associating domains
(TADs). How TADs are formed is not fully understood. Here, we combined high-throughput …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Highlights•Chromatin folding into topologically associated domains (TADs) is pervasive
across animal groups.•TADs are plastic entities composed of genomic strata from different …

Chromosome conformation capture technologies have revealed important insights into
genome folding. Yet, how spatial genome architecture is related to gene expression and cell …

A new level of chromosome organization, topologically associating domains (TADs), was
recently uncovered by chromosome conformation capture (3C) techniques. To explore TAD …

Experiments based on chromosome conformation capture have shown that mammalian
genomes are partitioned into topologically associating domains (TADs), within which the …

Chromatin architecture is fundamental in regulating gene expression. To investigate when
spatial genome organization is first established during development, we examined …

Chromosome conformation capture and orthologous methods uncovered the spatial
organization of metazoan chromosomes into autonomously folded substructures, often …