[HTML][HTML] Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid

W Wei, CC Wong, Z Jia, W Liu, C Liu, F Ji, Y Pan… - Nature …, 2023 - nature.com
Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease,
and is characterized by liver inflammation and fat accumulation. Dietary interventions, such …

[HTML][HTML] Commensal microbe-derived acetate suppresses NAFLD/NASH development via hepatic FFAR2 signalling in mice

R Aoki, M Onuki, K Hattori, M Ito, T Yamada… - Microbiome, 2021 - Springer
Background Non-alcoholic liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome, and it can progress to non-alcoholic steatohepatitis (NASH). Alterations in the gut …

The role of the microbiome in NAFLD and NASH

AA Kolodziejczyk, D Zheng, O Shibolet… - EMBO molecular …, 2019 - embopress.org
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of cardiometabolic
syndrome, which often also includes obesity, diabetes, and dyslipidemia. It is rapidly …

[HTML][HTML] Non-alcoholic fatty liver and the gut microbiota

S Bashiardes, H Shapiro, S Rozin, O Shibolet… - Molecular …, 2016 - Elsevier
Background Non-alcoholic fatty liver (NAFLD) is a common, multi-factorial, and poorly
understood liver disease whose incidence is globally rising. NAFLD is generally …

[HTML][HTML] Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic …

D Zhou, J Zhang, C Xiao, C Mo, BS Ding - Frontiers in Immunology, 2022 - frontiersin.org
Liver fibrosis is one main histological characteristic of nonalcoholic steatohepatitis (NASH),
a disease paralleling a worldwide surge in metabolic syndromes with no approved …

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

L Hoyles, JM Fernández-Real, M Federici, M Serino… - Nature medicine, 2018 - nature.com
Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is
a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal …

[HTML][HTML] Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

G Lee, HJ You, JS Bajaj, SK Joo, J Yu, S Park… - Nature …, 2020 - nature.com
Nonalcoholic fatty liver disease (NAFLD) is associated with obesity but also found in non-
obese individuals. Gut microbiome profiles of 171 Asians with biopsy-proven NAFLD and 31 …

Longitudinal 16S rRNA sequencing reveals relationships among alterations of gut microbiota and nonalcoholic fatty liver disease progression in mice

A Zhuge, S Li, P Lou, W Wu, K Wang, Y Yuan… - Microbiology …, 2022 - Am Soc Microbiol
Nonalcoholic fatty liver disease (NAFLD) is a prevalent and progressive disease spectrum
ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH), yet …

[HTML][HTML] Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

Y Lei, L Tang, Q Chen, L Wu, W He, D Tu… - Nature …, 2022 - nature.com
Nonalcoholic steatohepatitis (NASH) has been linked with the gut-liver axis. Here, we
investigate the potential for repurposing disulfiram (DSF), a drug commonly used to treat …

[HTML][HTML] Lentinan supplementation protects the gut–liver axis and prevents steatohepatitis: The role of gut microbiota involved

X Yang, M Zheng, M Zhou, L Zhou, X Ge, N Pang… - Frontiers in …, 2022 - frontiersin.org
The microbiota–gut–liver axis has emerged as an important player in developing
nonalcoholic steatohepatitis (NASH), a type of nonalcoholic fatty liver disease (NAFLD) …