Angiopoietins have been increasingly implicated to play important roles in blood vessel
formation, remodeling, maturation, and maintenance. However, their roles in tumor …

Members of the Angiopoietin family regulate various aspects of physiologic and pathologic
angiogenesis. Although Angiopoietin-1 (Ang-1) decreases endothelial cell permeability and …

Angiopoietin (Ang)-1 and-2, and mouse Ang-3/human Ang-4 are ligands of the receptor
tyrosine kinase with immunoglobulin and epidermal growth factor homology domains (Tie) …

Angiopoietin-1 is a promoter of physiological vasculogenesis and angiogenesis because it
induces vascular branching and smooth muscle recruitment to newly formed blood vessels …

The maturation of blood vessels requires mural cell adhesion to endothelial cells.
Angiopoietin‐1 (Ang1), a ligand for Tie2 receptor expressed on endothelial cells, plays a …

To define a role for the angiopoietin/Tie2 system in astrocytoma angiogenesis, we examined
the expression of angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) in these tumors by …

Abstract Angiopoietin-2 (Ang-2) is a conditional antagonist and agonist for the endothelium-
specific Tie-2 receptor. Although endogenous Ang-2 cooperates with vascular endothelial …

We addressed the effect of angiopoietin expression on tumor growth and metastasis.
Overexpression of angiopoietin-2 (Ang-2) in Lewis lung carcinoma and TA3 mammary …

Tie-1 and Tie-2 tyrosine kinase receptors are expressed specifically on vascular endothelial
cells and on a certain subtype of macrophages implicated in angiogenesis, thus, they have …

Abstract BACKGROUND Angiopoietin‐1 (Ang‐1) and angiopoietin‐2 (Ang‐2) are important
regulators of endothelial cell (EC) survival. Current models suggest that an increase in Ang …