Congenital hyperinsulinism (CHI), characterized by profound hypoglycaemia related to
inappropriate insulin secretion, may be associated histologically with either diffuse insulin …

Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous entity and
causes severe hypoglycemia in neonates and infants. The clinical heterogeneity is …

Congenital hyperinsulinism (CHI) is a disease phenotype characterized by increased,
usually irregular, insulin secretion leading to hypoglycemia, coma, and severe brain …

Congenital hyperinsulinism (CHI), previously named persistent hyperinsulinemic
hypoglycemia of infancy, is characterized by profound hypoglycemia because of excessive …

Congenital hyperinsulinism (HI) is most commonly caused by recessive mutations of the
pancreatic β-cell ATP-sensitive potassium channel (KATP), encoded by two genes on …

Neonatal hyperinsulinism (HI) is a clinical syndrome of pancreatic β-cell dysfunction
characterized by failure to suppress insulin secretion in the presence of hypoglycemia …

Background: Congenital hyperinsulinism (CHI) is associated with focal hyperplasia of
endocrine tissue in 40–65% of patients. Focal CHI is sporadic and is caused by a germline …

Congenital hyperinsulinism is a condition of dysregulated insulin secretion often caused by
inactivating mutations of the ATP-sensitive K+ (KATP) channel in the pancreatic β cell …

Congenital hyperinsulinism (CHI) is the most important cause of persistent hypoglycaemia in
the neonate and infant. It is a clinically and genetically heterogeneous entity. The clinical …

Hyperinsulinism is the single most common mechanism of hypoglycemia in neonates.
Dysregulated insulin secretion is responsible for the transient and prolonged forms of …