Identification of common candidate genes and pathways for Spina Bifida and Wilm's Tumor using an integrative bioinformatics analysis

N Tamkeen, A Farooqui, A Alam, Najma… - Journal of …, 2024 - Taylor & Francis
Abstract Spina Bifida (SB) and Wilm's Tumor (WT) are conditions, both associated with
children. Several studies have shown that WT later develops in SB patients, which led us to …

An in silico analysis of deleterious single nucleotide polymorphisms and molecular dynamics simulation of disease linked mutations in genes responsible for …

S Pandey, K Dhusia, P Katara, S Singh… - Journal of Biomolecular …, 2020 - Taylor & Francis
Mutation in two genes deglycase gene (DJ-1) and retromer complex component gene
(VPS35) are linked with neurodegenerative disorder such as Parkinson's disease …

[HTML][HTML] Network biology approaches to identify the drug lead molecule for neurodevelopmental disorders in human

A Verma, SS Chauhan, V Pankaj… - The Open …, 2020 - openbioinformaticsjournal.com
Aims: To identify most novel drug target and lead molecule for neurodevelopmental disorder
Autism, Intellectual Disability (ID) and Attention Deficit Hyperactivity Disorder (ADHD) …

Bioinformatics and cheminformatics approaches to identify pathways, molecular mechanisms and drug substances related to genetic basis of cervical cancer

KMS Andalib, MH Rahman, A Habib - Journal of Biomolecular …, 2023 - Taylor & Francis
Cervical cancer (CC) is a global threat to women and our knowledge is frighteningly little
about its underlying genomic contributors. Our research aimed to understand the underlying …

Structural Analysis of Leukemia Related Gene Network

S Wang, X Wang, Y Zhang, W Liu - Journal of Computational …, 2015 - ingentaconnect.com
Genome forms gene networks in the complicated interactive ways and further study on the
cancerrelated gene networks can help to understand and predict many unknown biological …

[HTML][HTML] The potential mechanisms of neuroblastoma in children based on bioinformatics big data

ZF Chen, LZ Wu, ZT Chen, LJ Su, CJ Fu - Translational Pediatrics, 2022 - ncbi.nlm.nih.gov
Background In recent years, miRNAs have become a research hotspot, which is related to
the occurrence and development of a variety of malignant tumors, but there are few studies …

Identification of crucial candidate genes and pathways in glioblastoma multiform by bioinformatics analysis

AM Alshabi, B Vastrad, IA Shaikh, C Vastrad - Biomolecules, 2019 - mdpi.com
The present study aimed to investigate the molecular mechanisms underlying glioblastoma
multiform (GBM) and its biomarkers. The differentially expressed genes (DEGs) were …

Integrated systems biology approach using gene network analysis to identify the important pathways and new potential drug targets for Neuroblastoma

G Ashok, SK Miryala, A Anbarasu, S Ramaiah - Gene Reports, 2021 - Elsevier
The complex and heterogeneous nature of neuroblastoma poses a great challenge to the
scientific community for developing an effective therapeutic drug. Neuroblastoma tumors …

Integrated gene expression profiling and functional enrichment analyses to discover biomarkers and pathways associated with Guillain-Barré syndrome and autism …

RA Hasib, MC Ali, MH Rahman, S Ahmed… - Journal of …, 2023 - Taylor & Francis
Guillain-Barré syndrome (GBS) is one of the most prominent and acute immune-mediated
peripheral neuropathy, while autism spectrum disorders (ASD) are a group of …

[PDF][PDF] Construction of a protein-protein interaction network of Wilms' tumor and pathway prediction of molecular complexes

WJ Teng, C Zhou, LJ Liu, XJ Cao, J Zhuang… - Genet Mol …, 2016 - funpecrp.com.br
Wilms' tumor (WT), or nephroblastoma, is the most common malignant renal cancer that
affects the pediatric population. Great progress has been achieved in the treatment of WT …