Research on all stages of fibrin polymerization, using a variety of approaches including
naturally occurring and recombinant variants of fibrinogen, x-ray crystallography, electron …

To test the validity of a proposed two step fibrin assembly mechanism and directly visualize
the molecular species present at various stages of fibrin formation, we have carried out an …

Fibrinogen is a complex multifunctional protein comprised of three major domains (two outer
D and one central E) which contains constitutive binding sites (eg Da, Db,[gamma] XL, D …

Thrombin cleaves A fibrinopeptides from fibrinogen faster than B; cleavage of the B
fibrinopeptides has been associated with enhanced lateral aggregation in the fibrin clot. We …

In order to arrive at a quantitative description of the molecular mechanism ef fibrin assembly,
we may begin with a minimum sequence of three consecutive reactions, a scheme that is …

The final phase of in vivo thrombus formation involves generation of a fibrin clot which
provides the major structural support and scaffolding for the cellular and other blood …

Fibrinogen is a large, complex, fibrous glycoprotein with three pairs of polypeptide chains
linked together by 29 disulfide bonds. It is 45 nm in length, with globular domains at each …

The locations of the carboxyl-terminal two thirds of the A alpha chains, or the alpha C
domains, were determined for fibrinogen and some of its derivatives by electron microscopy …

We identified the two-stranded fibrin protofibril and studied its structure in electron
micrographs of negatively stained specimens. Based on these images and on …

The inhibition of blood clotting by degradation products of fibrinogen reflects an interference
with fibrin network formation. The original discovery that digestion of fibrinogen by plasmin …