Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs)
within a vascular bed; however, little is known about how distinct endothelial subpopulations …

Pulmonary endothelial cells (ECs) are an essential component of the gas exchange
machinery of the lung alveolus. Despite this, the extent and function of lung EC …

A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC)
homeostasis; however, the understanding of how different cell populations contribute to this …

Background: Cellular diversity of the lung endothelium has not been systematically
characterized in humans. We provide a reference atlas of human lung endothelial cells …

Blood vessels are lined by endothelial cells engaged in distinct organ-specific functions but
little is known about their characteristic gene expression profiles. RNA-Sequencing of the …

Background: Endothelial cells (ECs) display considerable functional heterogeneity
depending on the vessel and tissue in which they are located. Whereas these functional …

Lung regeneration deteriorates with aging leading to increased susceptibility to pathologic
conditions, including fibrosis. Here, we investigated bleomycin-induced lung injury …

Repair of the endothelial cell barrier after inflammatory injury is essential for tissue fluid
homeostasis and normalizing leukocyte transmigration. However, the mechanisms of …

Many lung diseases result from a failure of efficient regeneration of damaged alveolar
epithelial cells (AECs) after lung injury. During regeneration, AEC2s proliferate to replace …

Lung injury activates quiescent stem and progenitor cells to regenerate alveolar structures.
The sequence and coordination of transcriptional programs during this process has largely …