BACKGROUND: Most antidepressant medications in current use have several
disadvantages: a delayed therapeutic effect, side effects, stigmatization and concerns about …

Background Chronotherapy (sleep deprivation, sleep phase shifting and/or the use of bright
light) combines non-invasive and non-pharmacological interventions that may act rapidly …

Alteration of the sleep–wake cycle and of the sleep structure are core symptoms of a major
depressive episode, and occur both in course of bipolar disorder and of major depressive …

Depression is a significant public health issue, made worse by the absence of response to
antidepressant medications by many patients. Given the high degree of overlap between …

Background Triple chronotherapy (wake night [one night without sleep], sleep phase
advance, and early morning bright light exposure) demonstrated rapid efficacy primarily in …

Background Given the strong relationship between circadian rhythm disruption and mood
regulation, combined chronotherapeutic approaches have been proposed for mood …

Psychiatric chronotherapeutics is the controlled exposure to environmental stimuli that act
on biological rhythms in order to achieve therapeutic effects in the treatment of psychiatric …

The global prevalence of depression is increasing, along with rates of depression-
associated disability and mortality, rendering depressive disorders a major public health …

There is growing evidence for combined chronotherapeutic interventions as adjunctive
treatments for major depression. However, as the treatments can be demanding, we need to …

Objective: Sleep and circadian disturbance is highly comorbid with a range of psychological
disorders, especially major depressive disorder (MDD). In view of the complexity of sleep …