Alterations in gene expression in the dorsal striatum caused by chronic cocaine exposure
have been implicated in the long-term behavioral changes associated with cocaine …

Sleep loss or disturbances are likely to signal an increased risk of future suicidal action in
adolescents. Large-scale prospective studies and neurobiological studies are needed for a …

Sensitive developmental periods shape neural circuits and enable adaptation. However,
they also engender vulnerability to factors that can perturb developmental trajectories. An …

Substance addiction may follow a chronic, relapsing course and critically undermine the
physical and psychological well‐being of the affected individual and the social units of which …

Research on the inter-relationship between drug abuse and social stress has primarily
focused on the role of stress exposure during adulthood and more recently, adolescence …

Repeated exposure to stress during childhood is associated with increased risk for
neuropsychiatric illness, substance use disorders and other behavioral problems in …

Childhood and adolescent adversity are associated with a wide range of psychiatric
disorders, including an increased risk for substance abuse. Despite this, the mechanisms …

Understanding how specific genes contribute to risk for addiction remains challenging. This
study tests whether childhood temperament and externalizing behavior in early adolescence …

Blunted stress reactivity resulting from early exposure to stress during childhood and
adolescence may increase vulnerability to addiction. Early life adversity (ELA) affects brain …

The majority of the literature describing the relation of sleep/alertness disturbance and
substance use disorders (SUD) has focused on the disruptive effects of substances with …