The mechanisms underlying the pathogenesis of chronic lung diseases, including chronic
obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis, remain …

Mitochondria regulate not only cell functions through energy generation but also aging-
associated cell phenotypes. Impaired mitochondrial structural and functional integrity …

Background Epithelial cell death is a major contributor to fibrogenesis in the lung. In this
study, we sought to determine the function of mitochondria and their clearance (mitophagy) …

The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but
involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as …

Once thought of in terms of bioenergetics, mitochondria are now widely accepted as both the
orchestrator of cellular health and the gatekeeper of cell death. The pulmonary disease field …

Mitochondria are indispensable for energy metabolism and cell signaling. Mitochondrial
homeostasis is sustained with stabilization of mitochondrial membrane potential, balance of …

Remarkable new roles for mitochondria in calcium handling, apoptosis, heme turnover,
inflammation, and oxygen and nutrient sensing have been discovered for organelles that …

Mechanisms underlying the pathogenesis of pulmonary fibrosis remain incompletely
understood. Emerging evidence suggests changes in mitochondrial quality control are a …

The renascence in mitochondrial research has fueled breakthroughs in our understanding of
mitochondrial biology identifying major roles in biological processes ranging from cellular …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …