The POU-domain transcription factor Oct-4 is normally expressed in pluripotent cells of the
mammalian embryo. In addition, germ-cell tumors and a few somatic tumors show …

Octamer-binding transcription factor 4 (Oct4) encodes a POU-domain transcription factor
(Scholer et al., 1990). The gene is specifically expressed in embryonic stem (ES) cells but …

The POU family transcription factor OCT4 is required for maintaining the pluripotency of
embryonic stem cells and for generating induced pluripotent stem cells. Although OCT4 is …

Transcription factors, such as Oct4, are critical for establishing and maintaining pluripotent
cell identity. Whereas the genomic locations of several pluripotency transcription factors …

Cell type specification relies on the capacity of undifferentiated cells to properly respond to
specific differentiation-inducing signals. Using genomic approaches along with loss-and …

Embryonic stem cell (ESC) pluripotency is governed by a gene regulatory network centered
on the transcription factors Oct4 and Nanog. To date, robust self-renewing ESC states have …

Background Oct4 is a key factor of an expanded transcriptional network (Oct4-TN) that
governs pluripotency and self-renewal in embryonic stem cells (ESCs) and in the inner cell …

Background: OCT3/4 (POU5F1) is an established diagnostic immunohistochemical marker
for specific histological variants of human malignant germ cell tumours (GCTs), including the …

The activation of endogenous Oct4 transcription is a key step in the reprogramming of
somatic cells into induced pluripotent stem (iPS) cells but until now it has been difficult to …

Previous reports showed that mouse vaccination with pluripotent stem cells (PSCs) induces
durable anti-tumor immune responses via T cell recognition of some elusive oncofetal …