U-Rich Sequence-Binding Proteins (URBPs) Interacting with a 20-Nucleotide U-Rich Sequence in the 3′ Untranslated Region of c-fos mRNA May Be Involved in the First Step …
Y You, CYA Chen, AB Shyu - Molecular and cellular biology, 1992 - Taylor & Francis
Rapid decay of the c-fos transcript plays a critical role in controlling transforming potential of
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
the c-fos proto-oncogene. One of the mRNA instability determinants is a 75-nucleotide AU …
Interplay of two functionally and structurally distinct domains of the c-fos AU-rich element specifies its mRNA-destabilizing function
CY Chen, TM Chen, AB Shyu - Molecular and cellular biology, 1994 - Am Soc Microbiol
AU-rich elements (ARE) in the 3′ untranslated region of many highly labile mRNAs for
proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The …
proto-oncogenes, lymphokines, and cytokines can act as an RNA-destabilizing element. The …
Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements
CYA Chen, AB Shyu - Molecular and cellular biology, 1994 - Taylor & Francis
The metabolic lifetime of mRNA can be specified by specific cis-acting elements within
mRNA. One type of element is an adenylate-and uridylate-rich element (ARE) found in the …
mRNA. One type of element is an adenylate-and uridylate-rich element (ARE) found in the …
[HTML][HTML] Multiple elements in the c-fos protein-coding region facilitate mRNA deadenylation and decay by a mechanism coupled to translation.
SC Schiavi, CL Wellington, AB Shyu, CY Chen… - Journal of biological …, 1994 - Elsevier
The c-fos proto-oncogene transcript is one of the most labile mammalian mRNAs known.
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …
Rapid degradation of c-fos mRNA is mediated by both the c-fos protein-coding region and …
The c-fos transcript is targeted for rapid decay by two distinct mRNA degradation pathways.
AB Shyu, ME Greenberg, JG Belasco - Genes & development, 1989 - genesdev.cshlp.org
Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene
expression. Experiments were performed to investigate the cellular mechanisms responsible …
expression. Experiments were performed to investigate the cellular mechanisms responsible …
Removal of an mRNA destabilizing element correlates with the increased oncogenicity of proto-oncogene fos.
V Raymond, JA Atwater, IM Verma - Oncogene research, 1989 - europepmc.org
AU-sequence motifs present in the 3'untranslated region (UTR) of many rapidly inducible
messenger RNAs have been proposed to mediate their selective degradation. We have …
messenger RNAs have been proposed to mediate their selective degradation. We have …
Deadenylylation: a mechanism controlling c-fos mRNA decay
ME Greenberg, AB Shyu, JG Belasco - Enzyme, 1990 - karger.com
The c-fos proto-oncogene mRNA is extremely labile and is rapidly degraded within minutes
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …
after being transported to the cytoplasm of growth factor-stimulated fibroblasts. Analysis of …
5′ untranslated sequences modulate rapid mRNA degradation mediated by 3′ AU-rich element in v-/c- fos recombinants
N Roy, G Laflamme, V Raymond - Nucleic acids research, 1992 - academic.oup.com
One major determinant of rapid mRNA decay is the presence of AU-rich sequences located
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …
in 3′ untranslated regions (UTR). To assess for the contribution of upstream sequences on …
The Destabilizing Elements in the Coding Region of c-fos mRNA Are Recognized as RNA
CL Wellington, ME Greenberg… - Molecular and cellular …, 1993 - Taylor & Francis
The protein-coding region of the c-fos proto-oncogene transcript contains elements that
direct the rapid deadenylation and decay of this mRNA in mammalian cells. The function of …
direct the rapid deadenylation and decay of this mRNA in mammalian cells. The function of …
AU-rich mRNA instability elements on human papillomavirus type 1 late mRNAs and c-fos mRNAs interact with the same cellular factors
M Sokolowski, C Zhao, W Tan, S Schwartz - Oncogene, 1997 - nature.com
Expression levels of human papillomavirus type 1 late genes are determined in part by an
AU-rich inhibitory sequence in the 3′ untranslated region on the late mRNAs. Fine …
AU-rich inhibitory sequence in the 3′ untranslated region on the late mRNAs. Fine …