[HTML][HTML] Ferroptosis: a promising target for cancer immunotherapy

LL Sun, DL Linghu, MC Hung - American journal of cancer …, 2021 - ncbi.nlm.nih.gov
Ferroptosis is a recently recognized type of programmed cell death and emerges to play an
important role in cancer biology and therapies. This unique form of cell death, characterized …

Targeting ferroptosis to iron out cancer

B Hassannia, P Vandenabeele, TV Berghe - Cancer cell, 2019 - cell.com
One of the key challenges in cancer research is how to effectively kill cancer cells while
leaving the healthy cells intact. Cancer cells often have defects in cell death executioner …

Ferroptosis in gastrointestinal cancer: from mechanisms to implications

R Zhang, R Kang, D Tang - Cancer Letters, 2023 - Elsevier
Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation
that results in plasma membrane damage and the release of damage-associated molecular …

Emerging mechanisms and disease relevance of ferroptosis

BR Stockwell, X Jiang, W Gu - Trends in cell biology, 2020 - cell.com
Cell death is an essential feature of development in multicellular organisms, a critical driver
of degenerative diseases, and can be harnessed for treating some cancers. Understanding …

Ferroptosis in the tumor microenvironment: perspectives for immunotherapy

H Xu, D Ye, M Ren, H Zhang, F Bi - Trends in molecular medicine, 2021 - cell.com
Targeting ferroptosis, which provokes lipid peroxidation in cancer cells, presents potentially
new avenues for anticancer therapy. Recent studies have begun to explore how immune …

Ferroptosis: past, present and future

J Li, F Cao, H Yin, Z Huang, Z Lin, N Mao, B Sun… - Cell death & …, 2020 - nature.com
Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …

Role of intracellular iron in switching apoptosis to ferroptosis to target therapy-resistant cancer stem cells

SL Pandrangi, P Chittineedi, SS Chalumuri, AS Meena… - Molecules, 2022 - mdpi.com
Iron is a crucial element required for the proper functioning of the body. For instance,
hemoglobin is the vital component in the blood that delivers oxygen to various parts of the …

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

N Xing, Q Du, S Guo, G Xiang, Y Zhang, X Meng… - Cell Death …, 2023 - nature.com
Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …

Ferroptosis, radiotherapy, and combination therapeutic strategies

G Lei, C Mao, Y Yan, L Zhuang, B Gan - Protein & cell, 2021 - academic.oup.com
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …

Transcriptional repression of ferritin light chain increases ferroptosis sensitivity in lung adenocarcinoma

Y Wang, S Qiu, H Wang, J Cui, X Tian… - Frontiers in cell and …, 2021 - frontiersin.org
Ferroptosis is an iron-and lipid peroxidation-dependent form of regulated cell death. The
release of labile iron is one of the important factors affecting sensitivity to ferroptosis. Yes …