Introduction The use of the 5-alpha reductase inhibitors (5-ARIs) finasteride and dutasteride
for prostate cancer prevention is still under debate. The FDA recently concluded that the …

The safety of using finasteride as a prevention of prostate cancer is still under debate. In this
study, we investigated the effects of finasteride on the location, gene expression and …

BACKGROUND Although finasteride is recognized for its role as a chemopreventive agent
for prostate cancer, higher grades of malignancy have been reported. It is questioned …

Abstract Background In the Prostate Cancer Prevention Trial, finasteride selectively
suppressed low-grade prostate cancer and significantly reduced the incidence of prostate …

BACKGROUND This study investigated the effects of finasteride, a 5α‐reductase inhibitor,
clinically used for the treatment of benign prostatic hyperplasia (BPH) on prostate tumor …

Summary Finasteride (Fin) and Doxazosin (Dox), alone or in combination, have been widely
used in treatment of benign prostatic hyperplasia (BPH) symptoms and recently have been …

Background: The Prostate Cancer Prevention Trial has shown a protective effect of
finasteride on prostate cancer, but it also showed that finasteride can increase the risk of …

PURPOSE: We explored the molecular correlates of the effect of finasteride on prostate
tissue in patients undergoing radical prostatectomy. MATERIALS AND METHODS: Patients …

Objective In the Prostate Cancer Prevention Trial (PCPT), finasteride reduced the risk of
prostate cancer by 25%, even though high-grade prostate cancer was more common in the …

BACKGROUND Normal and pathologic growth of the prostate is dependent on the synthesis
of dihydrotestosterone (DHT) from testosterone by 5α‐reductase. Finasteride is a selective …