ABSTRACT Introduction Polo Like Kinase 1 (PLK1) is a key regulator of mitosis and its
overexpression is frequently observed in a wide variety of human cancers, while often being …

Members of polo-like kinases (collectively, Plks) have been identified in various eukaryotic
organisms and play pivotal roles in cell proliferation. They are characterized by the presence …

Abstract Polo‐like kinase 1 (Plk1), a key player in mitosis, is overexpressed in a wide range
of tumor types and has been validated as a target for tumor therapy. In addition to its N …

As a mitotic-specific target widely deregulated in various human cancers, polo-like kinase 1
(Plk1) has been extensively explored for anticancer activity and drug discovery. Although …

Abstract Polo-like kinase 1 (PLK1) is a serine/threonine-protein kinase involved in cell cycle
regulation and mitotic progression. Studies have shown that PLK1 is upregulated in many …

Abstract Polo‐like kinase 1 (Plk1), a validated cancer target, harbors a protein–protein
interaction domain referred to as the polo‐box domain (PBD), in addition to its enzymatic …

The polo-box domain (PBD) of Plk1 is a promising target for cancer therapeutics. We
designed and synthesized novel phosphorylated macrocyclic peptidomimetics targeting …

Polo-like kinases (PLKs) are a family of serine/threonine kinases that play crucial roles in
multiple stages of mitosis. PLK1 is the most studied member of the family. It is overexpressed …

The polo-box domain (PBD) has critical roles in the mitotic functions of polo-like kinase 1
(PLK1). The replacement with partial ligand alternative through computational enrichment …

Polo-like kinase 1 (Plk1) is a central regulator of mitosis and has been validated as a target
for antitumor therapy. The polo-box domain (PBD) of Plk1 regulates its kinase activity and …