Emerging role of IL-6 and NLRP3 inflammasome as potential therapeutic targets to combat COVID-19: Role of lncRNAs in cytokine storm modulation
A Paniri, H Akhavan-Niaki - Life Sciences, 2020 - Elsevier
The world has witnessed a high morbidity and mortality caused by SARS-CoV-2, and global
death toll is still rising. Exaggerated inflammatory responses are thought to be more …
death toll is still rising. Exaggerated inflammatory responses are thought to be more …
[HTML][HTML] NLRP3 inflammasome activation in COVID-19: an interlink between risk factors and disease severity
NLRP3 inflammasome is a critical immune component that plays a crucial role in mounting
innate immune responses. The deleterious effects of inflammasome activation have been …
innate immune responses. The deleterious effects of inflammasome activation have been …
[HTML][HTML] Common NLRP3 inflammasome inhibitors and Covid-19: divide and conquer
Severe SARS-CoV-2 infection causes systemic inflammation, cytokine storm, and
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …
hypercytokinemia due to activation of the release of pro-inflammatory cytokines that have …
The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies
N Zhao, B Di, L Xu - Cytokine & growth factor reviews, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …
syndrome coronavirus 2 (SARS-CoV-2), exhibits a wide spectrum of clinical presentations …
[HTML][HTML] Interleukin-1 and the NLRP3 inflammasome in COVID-19: Pathogenetic and therapeutic implications
A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …
[HTML][HTML] NLRP3 inflammasome activation and SARS-CoV-2-mediated hyperinflammation, cytokine storm and neurological syndromes
Despite the introduction of vaccines and drugs for SARS-CoV-2, the COVID-19 pandemic
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …
continues to spread throughout the world. In severe COVID-19 patients, elevated levels of …
[HTML][HTML] Targeting the NLRP3 inflammasome in severe COVID-19
TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …
[HTML][HTML] Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice
J Zeng, X Xie, XL Feng, L Xu, JB Han, D Yu, QC Zou… - …, 2022 - thelancet.com
Summary Background The Coronavirus Disease 2019 (COVID-19) pandemic has been a
great threat to global public health since 2020. Although the advance on vaccine …
great threat to global public health since 2020. Although the advance on vaccine …
[HTML][HTML] Novel coronavirus-induced NLRP3 inflammasome activation: a potential drug target in the treatment of COVID-19
A Shah - Frontiers in immunology, 2020 - frontiersin.org
Novel coronaviruses (nCoVs) encode ion-channel proteins called viroporins such as protein
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …
E, open reading frame 3a (ORF3a) and ORF8a. These viroporins, via mechanisms such as …
[PDF][PDF] SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway
GR Campbell, RK To, J Hanna, SA Spector - Iscience, 2021 - cell.com
Macrophages promote an early host response to infection by releasing pro-inflammatory
cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically …
cytokines such as interleukin-1β (IL-1β), TNF, and IL-6. The bioactivity of IL-1β is classically …
相关搜索
- covid 19 nlrp3 inflammasome
- sars cov nlrp3 inflammasome
- interleukin 1 nlrp3 inflammasome
- covid 19 drug target
- covid 19 interleukin 1
- therapeutic strategies nlrp3 inflammasome
- covid 19 therapeutic strategies
- sars cov hiv 1
- sars cov cytokine storm
- pathology in mice nlrp3 inflammasome
- human macrophages nlrp3 inflammasome
- covid 19 pathology in mice
- covid 19 disease severity
- covid 19 risk factors
- therapeutic implications interleukin 1
- neurological syndromes cytokine storm