[HTML][HTML] Targeting interleukin-17 in chronic inflammatory disease: A clinical perspective

P Zwicky, S Unger, B Becher - Journal of Experimental Medicine, 2020 - rupress.org
Chronic inflammatory diseases like psoriasis, Crohn's disease (CD), multiple sclerosis (MS),
rheumatoid arthritis (RA), and others are increasingly recognized as disease entities, where …

Interleukin-17 as a drug target in human disease

S Ivanov, A Lindén - Trends in Pharmacological Sciences, 2009 - cell.com
Interleukin (IL)-17 (now synonymous with IL-17A) is an archetype molecule for an entire
family of IL-17 cytokines. Currently believed to be produced mainly by a specific subset of …

IL-17 signaling in host defense and inflammatory diseases

Y Qian, Z Kang, C Liu, X Li - Cellular & molecular immunology, 2010 - nature.com
Abstract Interleukin (IL)-17, the signature cytokine secreted by T helper (Th) 17 cells, plays
important roles in host defense against extracellular bacterial infection and fungal infection …

Targeting IL-17 in autoimmunity and inflammation

BS Kim, YJ Park, Y Chung - Archives of pharmacal research, 2016 - Springer
The discovery of two distinct subsets of helper T cells, IFN-γ-producing Th1 cells and IL-4-
producing Th2 cells, about three decades ago enabled us to understand the …

IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration

IE Adamopoulos, V Kuchroo - Nature Reviews Rheumatology, 2023 - nature.com
IL-17A and IL-17F in tissue homeostasis, inflammation and regeneration | Nature Reviews
Rheumatology Skip to main content Thank you for visiting nature.com. You are using a browser …

IL-17 in rheumatoid arthritis and precision medicine: from synovitis expression to circulating bioactive levels

M Robert, P Miossec - Frontiers in medicine, 2019 - frontiersin.org
Interleukin (IL)-17A has a direct contribution in early induction and late chronic stages of
various inflammatory diseases. In vitro and in vivo experiments have first characterized its …

Interleukin-15: a new cytokine target for the treatment of inflammatory diseases

IB McInnes, JA Gracie - Current opinion in pharmacology, 2004 - Elsevier
Interleukin (IL)-15 is a pleiotropic pro-inflammatory cytokine that is expressed in several
inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary …

IL-17 in chronic inflammation: from discovery to targeting

A Beringer, M Noack, P Miossec - Trends in molecular medicine, 2016 - cell.com
Interleukin-17 (IL-17) is a cytokine which elicits protection against extracellular bacterial and
fungal infections and which plays important roles in inflammation. However, when produced …

IL-17/IL-17 receptor system in autoimmune disease: mechanisms and therapeutic potential

S Zhu, Y Qian - Clinical science, 2012 - portlandpress.com
IL-17 (interleukin-17), a hallmark cytokine of Th17 (T-helper 17) cells, plays critical roles in
host defence against bacterial and fungal infections, as well as in the pathogenesis of …

IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases

X Song, Y Qian - Cellular signalling, 2013 - Elsevier
Inflammation is the immediate protective response of the body to pathogen invasions,
allergen challenges, chemical exposures or physical injuries. Acute inflammation usually …