Amiodarone is a widely used potent antiarrhythmic for the treatment of cardiac disease;
however, its use is often discontinued due to numerous adverse effects, including …

Amiodarone is a class III antiarrhythmic drug with potentially life-threatening hepatotoxicity.
Recent in vitro investigations suggested that the mono-N-desethyl (MDEA) and di-N …

Drug‐induced liver injury (DILI) is the most frequent cause of post‐marketing warnings and
withdrawals. Amiodarone (AMD), an antiarrhythmic, presents a risk of liver injury in humans …

Amiodarone is a potent antiarrhythmic drug with several limiting side effects, some of which
have been correlated with increased levels of its more toxic metabolite …

The aim of this work was to compare hepatocellular toxicity and pharmacological activity of
amiodarone (2-n-butyl-3-[3, 5 diiodo-4-diethylaminoethoxybenzoyl]-benzofuran; B2-O-Et-N …

Aims To predict the drug interactions of amiodarone and other drugs, the inhibitory effects
and inactivation potential for human cytochrome P450 (CYP) enzymes by amiodarone and …

Discussion Amiodarone is a commonly used antiarrhythmic. It is associated with
extracardiac side effects, including asymptomatic hepatic dysfunction in 15–40% of patients …

Background: Amiodarone is a well-known mitochondrial toxin consisting of a benzofuran
ring (ring A) coupled to a p-OH-benzene structure substituted with 2 iodines and a diethyl …

Amiodarone (AMD), a class III antiarrhythmic drug, causes idiosyncratic hepatotoxicity in
human patients. We demonstrated previously that tumor necrosis factor-alpha (TNF-α) plays …

The limited value of in vitro toxicity data for the in vivo extrapolation has been often attributed
to the lack of kinetic data. Here the in vitro kinetics of amiodarone (AMI) and its mono-N …