Adoptive immunotherapy with T cells expressing a tumor-specific chimeric T-cell receptor is
a promising approach to cancer therapy that has not previously been explored for the …

Despite the wealth of information that has been acquired regarding the way T cells
recognize their targets, we are left with far more questions than answers regarding how to …

Adoptive cell transfer after host preconditioning by lymphodepletion represents an important
advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment …

T-cell adoptive immunotherapy for stringent murine tumor models, such as intracranial, sc, or
advanced pulmonary metastases, routinely uses lymphodepletive conditioning regimens …

Despite advances in high-dose therapy with autologous stem cell transplantation for
lymphomas, relapse of the underlying disease remains a significant obstacle. Recent …

The success of allogeneic hematopoietic cell transplantation (HCT) for B-cell malignancies
is evidence that these tumors can be eliminated by T lymphocytes. This has encouraged the …

Allogeneic hematopoietic stem cell transplantation is currently the most effective method for
inducing tumor immunity. However, the diversity of target antigens recognized by donor T …

Solid tumours can be eradicated by infusion of large amounts of tumour-specific T-cells in
animal models. The successes seen in preclinical models, however, have not been …

Adoptive immunotherapy involves the transfer of immune effectors with antitumour activity
into the tumour bearing host. Early approaches such as lymphokine activator killer (LAK) …

Exciting developments in basic immunology and tumor biology have increased our
understanding of mechanisms of interactions between tumor cells and the immune system …