Programmed cell death in the germline

JS Baum, JPS George, K McCall - Seminars in Cell & Developmental …, 2005 - Elsevier
In many organisms, programmed cell death of germ cells is required for normal
development. This often occurs through highly conserved events including the transfer of …

Gonadal cell apoptosis.

AJ Hsueh, K Eisenhauer, SY Chun… - Recent Progress in …, 1996 - europepmc.org
Apoptosis is an important cellular process by which superfluous or unwanted cells are
deleted from an organism during tissue remodeling and differentiation. Recent studies have …

An elevated bax/bcl-2 ratio corresponds with the onset of prostate epithelial cell apoptosis

H Perlman, X Zhang, MW Chen, K Walsh… - Cell Death & …, 1999 - nature.com
The prostate gland in adult male rats is highly dependent on androgenic steroids. Castration
initiates the regression of this tissue through a process involving the loss of the vast majority …

Autonomous cell death of mouse male germ cells during fetal and postnatal period

RA Wang, PK Nakane, T Koji - Biology of reproduction, 1998 - academic.oup.com
Germ cell degeneration is common in mammalian testes during the developmental as well
as the adult period. To investigate the extent and mechanisms of male germ cell death …

Bcl-2 overexpression results in reciprocal downregulation of Bcl-XL and sensitizes human testicular germ cell tumours to chemotherapy-induced apoptosis

EL Arriola, AM Rodriguez-Lopez, JA Hickman… - Oncogene, 1999 - nature.com
Testicular germ cell tumours are hypersentive to chemotherapy and cell lines derived from
these tumours are chemosensitive in vitro. We have previously shown that these cell lines …

[PDF][PDF] Apoptosis precedes detachment of germ cells from the seminiferous epithelium after hormone suppression by short-term oestradiol treatment of rats

J Blanco-Rodriguez, C Martinez-Garcia - Int J Androl, 1998 - Wiley Online Library
Spermatogenesis is a highly synchronized process in which FSH and testosterone are
considered the major regulators. Nevertheless, the mechanism by which these hormones …

Detection of apoptotic alterations in sperm in subfertile patients and their correlations with sperm quality

HM Shen, J Dai, SE Chia, A Lim… - Human Reproduction, 2002 - academic.oup.com
BACKGROUND: The aim of the present study was to define the effect of apoptosis on sperm
quality and function. METHODS: The apoptotic features in sperm were assessed in 60 …

Spermatogonial stem cells

DG De Rooij, JA Grootegoed - Current opinion in cell biology, 1998 - Elsevier
The mammalian seminiferous epithelium consists of a highly complex yet well-organized
cell population, with germ cells in mitosis and meiosis and postmeiotic cells undergoing …

Apoptosis is physiologically restricted to a specialized cytoplasmic compartment in rat spermatids

J Blanco-Rodríguez… - Biology of reproduction, 1999 - academic.oup.com
Cytoplasmic caudal tags of maturing spermatids condense and are detached from the
spermatidal cells just before the spermatids are released as spermatozoa. The detached …

Significance of apoptosis in the temporal and stage-specific loss of germ cells in the adult rat after gonadotropin deprivation

AP Sinha Hikim, TB Rajavashisth, IS Hikim… - Biology of …, 1997 - academic.oup.com
The major objectives of the present study were to document the temporal and stage-specific
acceleration of germ cell apoptosis in adult rats after selective suppression of pituitary …