Oocyte loss, either directly through attrition (germ cell death) or indirectly through follicular
atresia (somatic or granulosa cell death), is a fundamental event associated with defining …

Bcl-w, a prosurvival member of the Bcl-2 family, is essential for spermatogenesis. However,
the mechanisms by which Bcl-w participates in the regulation of apoptosis in the testis are …

The BH3‐only proteins of the Bcl‐2 family initiate apoptosis through the activation of Bax‐
like relatives. Loss of individual BH3‐only proteins can lead either to no phenotype, as in …

The possible role of apoptosis in spontaneous or induced germ cell death was investigated
by treating adult male rats with either a GnRH antagonist (112.5 μg kg− 1 day− 1 for 14 …

Mammalian spermatogenesis requires a stem cell pool, a period of amplification of cell
numbers, the completion of reduction division to haploid cells (meiosis), and the …

The loss of ovarian follicles through atresia, which accounts for greater than 99% of
postnatal female germ cell depletion, is mediated through apoptotic cell death. Although …

A long-standing problem in epididymal physiology is the fate of unejaculated spermatozoa
in the cauda epididymidis under conditions such as congenital absence of the vas deferens …

The origin and development of the spermatogenic cell lineage is reviewed, as well as
spermatogonial kinetics in adult nonprimate mammals in relation to the cycle of the …

BACKGROUND: Caspases are downstream elements of apoptosis-mediating pathways
initiated by the Fas ligand/Fas receptor system which is supposed to play a central role in …

Spermatogonial stem cells (As spermatogonia) are single cells that either renew themselves
or produce Apr (paired) spermatogonia predestined to differentiate. In turn, the Apr divide …