Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract.

A Suzuki, A Matsuzawa, T Iguchi - Oncogene, 1996 - europepmc.org
Suppression of apoptosis by Bcl-2, an oncogene product, has been previously reported.
Although the down regulation of Bcl-2 has been encountered in various types of apoptosis …

Apoptosis in mouse primordial germ cells: a study by transmission and scanning electron microscope

M Pesce, M De Felici - Anatomy and embryology, 1994 - Springer
A detailed study of the death in vitro of mouse primordial germ cell (PGCs) by means of
transmission and scanning electron microscopy is reported. The results show that after 4–5 …

Deciphering the pathways of germ cell apoptosis in the testis

APS Hikim, Y Lue, M Diaz-Romero, PH Yen… - The Journal of steroid …, 2003 - Elsevier
A growing body of evidence demonstrates that germ cell death both spontaneous (during
normal spermatogenesis) and that induced by suppression of hormonal support or …

Apoptosis and proliferation of human testicular somatic and germ cells during prepuberty: high rate of testicular growth in newborns mediated by decreased apoptosis

EB Berensztein, MI Sciara, MA Rivarola… - The Journal of …, 2002 - academic.oup.com
Programmed cell death and proliferation are evolutionary conserved processes that play a
major role during normal development and homeostasis. In the testis, during the fetal and …

Expression of caspase and BCL-2 apoptotic family members in mouse preimplantation embryos

GE Exley, C Tang, AS McElhinny… - Biology of …, 1999 - academic.oup.com
Apoptosis, as determined by blastomere and DNA fragmentation, occurs in many
preimplantation mouse embryos. To investigate which genes contribute to apoptosis in …

Germ cell proliferation and apoptosis in the developing human ovary

N Fulton, SJ Martins da Silva, RAL Bayne… - The Journal of …, 2005 - academic.oup.com
Context: The regulation of germ cell proliferation and loss during human ovarian
development is poorly understood. This is of particular interest at the time leading up to the …

Critical components of testicular function and sensitivity to disruption

ML Meistrich - Biology of reproduction, 1986 - academic.oup.com
Toxic agents can interfere with the male reproductive system at many targets. Radiation and
cancer chemotherapeutic drugs represent one class of toxins the sterilizing effects of which …

Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads

DN Modi, S Sane, D Bhartiya - Molecular human reproduction, 2003 - academic.oup.com
The purpose of the study was to examine the occurrence of programmed cell death
(apoptosis) in normal and chromosomally aneuploid testis and ovaries during the second …

Testosterone Regulates Apoptosis in Adult Human Seminiferous Tubules in Vitro

K Erkkilä, K Henriksén, V Hirvonen… - The Journal of …, 1997 - academic.oup.com
In the present study an in vitro model was developed and characterized for evaluation of the
role of apoptosis in adult human testes. The samples came from adult men undergoing …

Spermatogenesis

DM de Kretser, KL Loveland, A Meinhardt… - Human …, 1998 - academic.oup.com
Spermatogenesis is a complex process involving mitotic cell division, meiosis and the
process of spermiogenesis. The regulation of spermatogenesis involves both endocrine and …