The present study investigates the molecular apoptotic pathway in germ cells following
acute ischemia of the rat testis. Rats were subjected to ischemia-inducing torsion and testes …

Each cell is under constant surveillance to maintain the integrity of its genome. Genomic
lesions in a cell must be repaired before the onset of DNA replication and cell division. In the …

A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic
pathway of cellular suicide that appears to be common to all multicellular animals. A related …

Recent data support a role for apoptosis, under tight regulatory control by bcl-2, oxidative
stress response, tumor suppressor, and CASP gene family members, in mediating …

Testicular germ cell apoptosis in the cryptorchid testis is induced by abdominal heat stress.
p53‐dependent apoptosis appears responsible for the initial phase of germ cell loss in …

Male germ cell apoptosis has been extensively explored in rodents. In contrast, very little is
known about the susceptibility of developing germ cells to apoptosis in response to busulfan …

Bcl-2 was first identified as a novel transcript associated with the t (14; 18) chromosomal
breakpoint which occurs in most follicular lymphomas. The deregulated expression of bcl-2 …

Although surgical induction of cryptorchidism in the rat is known to cause infertility due to
disruption of spermatogenesis, the exact cellular mechanism responsible for the …

Apoptosis is co-regulated by the conserved family of Bcl-2-related proteins, which includes
both its agonists (Bax) and antagonists (Bcl-XL). A mutant strain of the yeast Saccharomyces …

The reproductive system presents some of the best examples of programmed cell death,
which is to be expected considering the dramatic cycles of tissue growth and regression in …