Stress, overeating, and obesity: Insights from human studies and preclinical models

M Razzoli, C Pearson, S Crow… - … & Biobehavioral Reviews, 2017 - Elsevier
Eating disorders and obesity have become predominant in human society. Their association
to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity …

Dopaminergic and brain‐derived neurotrophic factor signalling in inbred mice exposed to a restricted feeding schedule

C Gelegen, J Van Den Heuvel… - Genes, Brain and …, 2008 - Wiley Online Library
Increased physical activity and decreased motivation to eat are common features in
anorexia nervosa. We investigated the development of these features and the potential …

Fuel not fun: Reinterpreting attenuated brain responses to reward in obesity

NB Kroemer, DM Small - Physiology & Behavior, 2016 - Elsevier
There is a well-established literature linking obesity to altered dopamine signaling and brain
response to food-related stimuli. Neuroimaging studies frequently report enhanced …

The neuropathology of obesity: insights from human disease

EB Lee, MP Mattson - Acta neuropathologica, 2014 - Springer
Obesity, a pathologic state defined by excess adipose tissue, is a significant public health
problem as it affects a large proportion of individuals and is linked with increased risk for …

[HTML][HTML] Habitual daily intake of a sweet and fatty snack modulates reward processing in humans

SE Thanarajah, AG DiFeliceantonio, K Albus… - Cell metabolism, 2023 - cell.com
Western diets rich in fat and sugar promote excess calorie intake and weight gain; however,
the underlying mechanisms are unclear. Despite a well-documented association between …

[PDF][PDF] Voluntary exercise improves hypothalamic and metabolic function in obese mice

BT Laing, K Do, T Matsubara, DW Wert, MJ Avery… - J …, 2016 - researchgate.net
Exercise plays a critical role in regulating glucose homeostasis and body weight. However,
the mechanism of exercise on metabolic functions associated with the CNS has not been …

An obesity-predisposing variant of the FTO gene regulates D2R-dependent reward learning

M Sevgi, L Rigoux, AB Kühn, J Mauer… - Journal of …, 2015 - Soc Neuroscience
Variations in the fat mass and obesity-associated (FTO) gene are linked to obesity. However,
the underlying neurobiological mechanisms by which these genetic variants influence …

How can drug addiction help us understand obesity?

ND Volkow, RA Wise - Nature neuroscience, 2005 - nature.com
How can drug addiction help us understand obesity? | Nature Neuroscience Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

The hardship of obesity: a soft-wired hypothalamus

TL Horvath - Nature neuroscience, 2005 - nature.com
Food intake and energy expenditure are determinants of metabolic phenotype and are
regulated by the CNS. Although humans have a well-balanced homeostatic feedback loop …

Nucleus accumbens cytoarchitecture predicts weight gain in children

KM Rapuano, JS Laurent… - Proceedings of the …, 2020 - National Acad Sciences
The prevalence of obesity in children and adolescents worldwide has quadrupled since
1975 and is a key predictor of obesity later in life. Previous work has consistently observed …