Background: During its persistence in cystic fibrosis (CF) airways, P. aeruginosa develops a
series of phenotypic changes by the accumulation of pathoadaptive mutations. A better …

Abstract Background Chronic infection with Pseudomonas aeruginosa is a major cause of
morbidity and mortality in cystic fibrosis (CF) patients, and a more complete understanding of …

The opportunistic pathogen Pseudomonas aeruginosa causes chronic airway infections in
patients with cystic fibrosis (CF), and it is directly associated with the morbidity and mortality …

Pulmonary infections caused by Pseudomonas aeruginosa are a recalcitrant problem in
cystic fibrosis (CF) patients. While the clinical implications and long-term evolutionary …

Chronic airway infections with Pseudomonas aeruginosa determine morbidity in most
individuals with cystic fibrosis (CF). P. aeruginosa may persist for decades in CF lungs …

ABSTRACT The Gram-negative bacterium Pseudomonas aeruginosa is a common cause of
chronic airway infections in individuals with the heritable disease cystic fibrosis (CF). After …

Pseudomonas aeruginosa populations undergo a characteristic evolutionary adaptation
during chronic infection of the cystic fibrosis (CF) lung, including reduced production of …

Highlights•Pseudomonas aeruginosa in CF airways: paradigm of bacterial microevolution.•
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …

Rationale: Pseudomonas aeruginosa, the predominant cause of chronic airway infections of
patients with cystic fibrosis, exhibits extensive phenotypic diversity among isolates within …

Pseudomonas aeruginosa exploits intrinsic and acquired resistance mechanisms to resist
almost every antibiotic used in chemotherapy. Antimicrobial resistance in P. aeruginosa …