Synthesis and Characterization of Palmitoyl-block-poly(methacryloyloxyethyl phosphorylcholine) Polymer Micelles for Anticancer Drug Delivery

M Zhang, Z Zhang, X Song, J Zhu, JA Sng, J Li… - …, 2022 - ACS Publications
We report the synthesis and characterization of an amphiphilic polymer comprising a
hydrophobic palmitoyl (Pal) group and a zwitterionic poly (2-methacryloyloxyethyl …

In vitro and in vivo anti-tumor efficiency comparison of phosphorylcholine micelles with PEG micelles

M Cai, J Cao, Z Wu, F Cheng, Y Chen, X Luo - Colloids and Surfaces B …, 2017 - Elsevier
Polymer micelles for anticancer drug delivery have shown many advantages. In this study,
poly (ε-caprolactone)-b-poly (2-methacryloyloxyethyl phosphorylcholine)(PCL-PMPC) with …

Enhancement of cellular uptake and antitumor efficiencies of micelles with phosphorylcholine

S Tu, YW Chen, YB Qiu, K Zhu… - Macromolecular …, 2011 - Wiley Online Library
Internalization of drug delivery micelles into cancer cells is a crucial step for antitumor
therapeutics. Novel amphiphilic star‐shaped copolymers with zwitterionic phosphorylcholine …

Biocompatible Poly(D,L‐lactide)‐block‐Poly(2‐methacryloyloxyethylphosphorylcholine) Micelles for Drug Delivery

GY Liu, LP Lv, CJ Chen, XF Hu… - … Chemistry and Physics, 2011 - Wiley Online Library
Well‐defined amphiphilic PLA‐b‐PMPC diblock copolymers were synthesized. Bimimetic
micelles were prepared and applied for release of anti‐cancer drugs (DOX). TEM and DLS …

Effects of copolymer component on the properties of phosphorylcholine micelles

Z Wu, M Cai, J Cao, J Zhang, X Luo - International Journal of …, 2017 - Taylor & Francis
Zwitterionic polymers have unique features, such as good compatibility, and show promise
in the application of drug delivery. In this study, the zwitterionic copolymers, poly (ε …

A pH‐Sensitive Phospholipid Polymeric Prodrug Based on Branched Polyethylenimine for Intracellular Drug Delivery

H Wang, J Xiong, G Liu, Y Wang - … Chemistry and Physics, 2016 - Wiley Online Library
A biomimic pH‐sensitive polymeric prodrug based on branched polyethylenimine‐graft‐12‐
acryloyloxy dodecyl phosphorylcholine and 6‐maleimidocaproyl‐doxorubicin is rationally …

Cellular uptake of pH/reduction responsive phosphorylcholine micelles

Y Cai, S Li, M Cai, Y Chen, X Luo - New Journal of Chemistry, 2017 - pubs.rsc.org
Phosphorylcholine micelles based on pH/reduction responsive copolymers, poly (ε-
caprolactone)-ss-b-poly ((N, N-diethylaminoethyl methacrylate)-r-poly (2 …

Drug carrier system self-assembled from biomimetic polyphosphorycholine and biodegradable polypeptide based diblock copolymers

G Liu, W Zhuang, X Chen, A Yin, Y Nie, Y Wang - Polymer, 2016 - Elsevier
Polymeric nanoscale drug carrier systems are of particular interest for tumor therapy, offering
significant advantages of improved targeting and efficacy. Herein, a well-defined polymeric …

Novel biomimetic polymersomes as polymer therapeutics for drug delivery

JP Xu, J Ji, WD Chen, JC Shen - Journal of controlled release, 2005 - Elsevier
Novel amphiphilic diblock copolymers, cholesterol-end-capped poly (2-methacryloyloxyethyl
phosphorylcholine)(CMPC), which have poly (2-methacryloyloxyethyl phosphorylcholine) …

Tracing difference: in vitro and in vivo antitumor property comparison of pH-sensitive biomimetic phosphorylcholine micelles with insensitive micelles

Q Wang, D Lei, F Chen, Y Chen… - ACS Biomaterials Science …, 2019 - ACS Publications
Although smart polymer micelles able to respond to the tumor acid microenvironment are
potential anticancer drug carriers, fruitful clinical application of these carriers is inadequate …