A series of benzo [h][1, 6] naphthyridine and azepino [3, 2-c] quinoline derivatives were
prepared and evaluated to determine the necessary requirements for high affinity on the 5 …

A series of 4-hydroxy-3-quinolinecarboxylic acid derivatives (6) and 4-hydroxy-2-oxo-1, 2-
dihydro-3-quinolinecarboxylic acid derivatives (7) were designed and synthesized as 5-HT3 …

ETHNOPHARMACOLOGICAL RELEVANCE: Geissospermum vellosii is a tree widely found
throughout the Amazonic forest and frequently used by the native population for painful …

Phenylalkylamines such as 1-(4-bromo-2, 5-dimethoxyphenyl)-2-aminopropane (DOB; 1a)
and its corresponding iodo derivative DOI (2) are commonly used 5-HT2 serotonin agonists …

Clinical studies with the fixed herbal combination product STW 5 (Iberogast®) have
indicated an efficacy comparable to metoclopramide (5-HT3 antagonist) and cisapride (5 …

AL-38022A is a novel synthetic serotonergic (5-HT) ligand that exhibited high affinity for
each of the 5-HT2 receptor subtypes (Ki≤ 2.2 nM), but a significantly lower (> 100-fold less) …

Introduction. The human 5-HT7 receptor is a recently discovered member of the seven-
transmembrane G-protein-coupled receptor superfamily. 2 The most abundant isoform 5 …

A series of new 1-[4-(indol-3-yl) butyl]-4-arylpiperazines was prepared to identify highly
selective and potent 5-HT1A agonists as potential pharmacological tools in studies of mood …

A library consisting of 60 arylpiperazines modified with N-acylated amino acids was
prepared on BAL linker SynPhase™ Lanterns and evaluated in vitro for 5-HT1A receptor …

Analogues of pindolol, 1-(1H-indol-4-yloxy)-3-isopropylamino-propan-2-ol, were
synthesized and evaluated as 5-HT1A receptor antagonists. The structural features required …