A series of N1-arylsulfonyl-3-(1, 2, 3, 6-tetrahydropyridin-4-yl) indole derivatives was
designed and synthesized. These compounds were shown to have high affinity for the 5 …

A series of new 1, 2, 4-benzothiadiazine derivatives with an arylpiperazine mojety linked at
position 3 of the heterocyclic ring were synthesized and assessed for their pharmacological …

A new series of epiminocyclohepta [b] indoles with potent 5-HT6 antagonist activity were
discovered and optimized using in vitro protocols. One compound from this series was …

5-Arylsulfonylamido-3-(pyrrolidin-2-ylmethyl)-1 H-indoles have been identified as high-
affinity 5-HT6 receptor ligands. Within this class, several of the (R)-enantiomers were potent …

Synthesis and evaluation of the activity of new 4-methyl-1, 2, 3, 4, 10, 10a-
hexahydropyrazino [1, 2-a] indoles as 5-HT2C receptor agonists are described …

In the course of a search for small-molecule inhibitors of 5-hydroxytryptamine receptors we
have identified a novel ergoline derivative (1) from the fungal culture of Dicyma sp. This …

A series of esters and amides of l-alkyl-2-oxo-1, 2-dihydroquinoline-4-carboxylic acid or 2-
alkoxy-quinoline-4-carboxylic acid containing a basic azabicycloalkyl moiety has been …

Both functional and radioligand binding studies indicate that 5‐HT 4 receptors are
expressed in the CNS of several species, including human brain. 1 In order to determine the …

It is thought that selective 5-HT4 receptor agonists—such as 4-amino-5-chloro-2-methoxy-N-
[1-(6-oxo-6-phenylhexyl) piperidin-4-ylmethyl] benzamide (2)—have the ability to enhance …

Ethnopharmacological relevance Dopamine receptors are long-standing primary targets in
the treatment of mental diseases and there is growing evidence that suggests relationships …