Baicalin Represses Type Three Secretion System of Pseudomonas aeruginosa through PQS System

P Zhang, Q Guo, Z Wei, Q Yang, Z Guo, L Shen… - Molecules, 2021 - mdpi.com
Therapeutics that target the virulence of pathogens rather than their viability offer a
promising alternative for treating infectious diseases and circumventing antibiotic resistance …

Baicalin inhibits biofilm formation, attenuates the quorum sensing-controlled virulence and enhances Pseudomonas aeruginosa clearance in a mouse peritoneal …

J Luo, B Dong, K Wang, S Cai, T Liu, X Cheng, D Lei… - PloS one, 2017 - journals.plos.org
The quorum sensing (QS) circuit plays a role in the precise regulation of genes controlling
virulence factors and biofilm formation in Pseudomonas aeruginosa. QS-controlled biofilm …

Attenuation of quorum sensing controlled virulence factors and biofilm formation in Pseudomonas aeruginosa by pentacyclic triterpenes, betulin and betulinic acid

J Rajkumari, S Borkotoky, A Murali, K Suchiang… - Microbial …, 2018 - Elsevier
The production of virulence determinants and biofilm formation in numerous pathogens is
regulated by the cell-density-dependent phenomenon, Quorum sensing (QS). The QS …

Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected …

J Luo, J Kong, B Dong, H Huang, K Wang… - Drug design …, 2016 - Taylor & Francis
Burgeoning antibiotic resistance and unfavorable outcomes of inflammatory injury after
Pseudomonas aeruginosa infection have necessitated the development of novel agents that …

Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system

A Yamazaki, J Li, Q Zeng, D Khokhani… - Antimicrobial agents …, 2012 - Am Soc Microbiol
Antibiotic therapy is the most commonly used strategy to control pathogenic infections;
however, it has contributed to the generation of antibiotic-resistant bacteria. To circumvent …

The Effects of Chinese Herbal Medicines on the Quorum Sensing-Regulated Virulence in Pseudomonas aeruginosa PAO1

YM Chong, KY How, WF Yin, KG Chan - Molecules, 2018 - mdpi.com
The quorum sensing (QS) system has been used by many opportunistic pathogenic bacteria
to coordinate their virulence determinants in relation to cell-population density. As antibiotic …

[HTML][HTML] Baicalin ameliorates multidrug-resistant Pseudomonas aeruginosa induced pulmonary inflammation in rat via arginine biosynthesis

L Li, H Cui, Y Zhang, W Xie, Y Lin, Y Guo… - Biomedicine & …, 2023 - Elsevier
Multidrug-resistance (MDR) Pseudomonas aeruginosa (P. aeruginosa) is a lethal gram-
negative pathogen causing hospital-acquired and ventilator-associated pneumonia, which …

New insights into the antibacterial and quorum sensing inhibition mechanism of Artemisia argyi leaf extracts towards Pseudomonas aeruginosa PAO1

J Kong, Y Wang, K Xia, N Zang, H Zhang, X Liang - 3 Biotech, 2021 - Springer
This study aimed to investigate the anti-quorum sensing (QS) activity of Artemisia argyi leaf
extracts (AALE) towards Pseudomonas aeruginosa PAO1 as well as the underlying …

Calpurnia aurea (Aiton) Benth Extracts Reduce Quorum Sensing Controlled Virulence Factors in Pseudomonas aeruginosa

S Cosa, JR Rakoma, AA Yusuf, TE Tshikalange - Molecules, 2020 - mdpi.com
Pseudomonas aeruginosa is the causative agent of several life-threatening human
infections. Like many other pathogens, P. aeruginosa exhibits quorum sensing (QS) …

Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa

VB Maisuria, YL Los Santos, N Tufenkji, E Déziel - Scientific reports, 2016 - nature.com
Bacteria have evolved multiple strategies for causing infections that include producing
virulence factors, undertaking motility, developing biofilms and invading host cells. N …