Classical models of intracellular signalling describe how small changes in a cell's external
environment can bring about major changes in cellular activity. Recent findings from …

Signaling networks usually include protein-modification cycles. Cascades of such cycles are
the backbones of multiple signaling pathways. Protein gradients emerge from the spatial …

Emerging evidence indicates that complex spatial gradients and (micro) domains of
signalling activities arise from distinct cellular localization of opposing enzymes, such as a …

Abstract In Systems Biology, spatial modelling allows an accurate description of phenomena
whose behaviour is influenced by the spatial arrangement of the elements. In this thesis, we …

In eucaryotic organisms, responses to external signals are mediated by a repertoire of
intracellular signalling pathways that ultimately bring about the activation/inactivation of …

Biochemical pathways and networks are central to cellular information processing. While a
broad range of studies have dissected multiple aspects of information processing in …

This comprehensively revised second edition of Computational Systems Biology discusses
the experimental and theoretical foundations of the function of biological systems at the …

The cell as a dynamical system presents the characteristics of having a dynamical structure.
That is, the exact phase space of the system cannot be fixed before the evolution and …

Systems biology has two general aims: a narrow one, which is to discover how complex
networks of proteins work, and a broader one, which is to integrate the molecular and …

The theory of behaviour-based systems (or autonomous agents) constitutes a useful
approach for the modelling of intracellular signalling networks. In this sense, a cell can be …