The specificity of mature CD8+ and CD4+ T lymphocytes is controlled by major
histocompatibility complex (MHC) class I and class II molecules, respectively. The MHC …

CLONAL deletion or clonal anergy establish tolerance in T cells that bear potentially
autoreactive antigen receptors1–15. Here we report that concomitant infection with the …

The specialized junction between a T lymphocyte and an antigen-presenting cell, the
immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring …

Excitement has been high in the immunological community, as animal and human studies
have suggested that autoimmune diseases can be prevented or inhibited by treatment with …

The expansion and contraction of specific helper T cells in the draining lymph nodes of
normal mice after injection with antigen was followed. T cell receptors from purified primary …

The concept of innate immunity refers to the first-line host defense that serves to limit
infection in the early hours after exposure to microorganisms. Recent data have highlighted …

A viral infection is a race. For the infected organism to survive, cell-mediated immunity has to
develop faster than the spread of the pathogen. The outcome depends on how many …

Only so-called" professional" antigen-presenting cells (APCs) of hematopoietic origin are
believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with …

The influence of antigen epitope density and order on B cell induction and antibody
production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana …

Obsolescent—such was once the view of the innate immune system. That view is itself out of
date. But a fresh angle of attack on the ways in which innate immunity is essential to the …