Alterations in the expression of chemokine mRNA levels in fibrosis-resistant and-sensitive mice after thoracic irradiation

CJ Johnston, TW Wright, P Rubin… - Experimental lung …, 1998 - Taylor & Francis
Fibrosis, characterized by the accumulation of collagen, is a consequence of a chronic
inflammatory response. The purpose of this study was to determine if the mRNA expression …

Radiation-induced pulmonary fibrosis: examination of chemokine and chemokine receptor families

CJ Johnston, JP Williams, P Okunieff… - Radiation …, 2002 - meridian.allenpress.com
Abstract Johnston, CJ, Williams, JP, Okunieff, P. and Finkelstein, JN Radiation-Induced
Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor Families. Radiat …

Early and persistent alterations in the expression of interleukin-1α, interleukin-1β and tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after …

CJ Johnston, B Piedboeuf, P Rubin… - Radiation …, 1996 - meridian.allenpress.com
Fibrosis, characterized by the accumulation of collagen, is a consequence of a chronic
inflammatory response. The purpose of this study was to determine if tumor necrosis factor α …

Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis

CJ Johnston, B Piedboeuf, R Baggs… - Radiation …, 1995 - meridian.allenpress.com
Fibrosis, characterized by the accumulation of collagen, is a late result of thoracic irradiation.
The purpose of this study was to determine if extracellular matrix protein and transforming …

Inflammatory cell recruitment following thoracic irradiation

CJ Johnston, JP Williams, A Elder… - Experimental lung …, 2004 - Taylor & Francis
Ionizing radiation leads to a progressive injury in which a monocyte/macrophage-rich
pneumonitis is followed by a chronic progressive fibrosis. In the present study, the role of …

Role of infiltrating monocytes in the development of radiation-induced pulmonary fibrosis

AM Groves, CJ Johnston, JP Williams… - Radiation …, 2018 - meridian.allenpress.com
Lung exposure to radiation induces an injury response that includes the release of cytokines
and chemotactic mediators; these signals recruit immune cells to execute inflammatory and …

The chemokine, CCL3, and its receptor, CCR1, mediate thoracic radiation–induced pulmonary fibrosis

X Yang, W Walton, DN Cook, X Hua… - American journal of …, 2011 - atsjournals.org
Patients receiving thoracic radiation often develop pulmonary injury and fibrosis. Currently,
there are no effective measures to prevent or treat these conditions. We tested whether …

CCL22 and CCL17 in rat radiation pneumonitis and in human idiopathic pulmonary fibrosis

T Inoue, S Fujishima, E Ikeda, O Yoshie… - European …, 2004 - Eur Respiratory Soc
Pulmonary fibrosis is caused by various known and unknown aetiologies, but the key
pathogenic mechanisms are still ill-defined. Chemokines are a large family of chemotactic …

Whole-lung irradiation results in pulmonary macrophage alterations that are subpopulation and strain specific

AM Groves, CJ Johnston, RS Misra… - Radiation …, 2015 - meridian.allenpress.com
Exposure of the lung to radiation produces injury and inflammatory responses that result in
microenvironmental alterations, which can promote the development of pneumonitis and/or …

[HTML][HTML] Radiation produces differential changes in cytokine profiles in radiation lung fibrosis sensitive and resistant mice

X Ao, L Zhao, MA Davis, DM Lubman… - Journal of hematology & …, 2009 - Springer
Background Recent research has supported that a variety of cytokines play important roles
during radiation-induced lung toxicity. The present study is designed to investigate the …